Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Paneer Deralakatte Mangalore-574160, India.
Biomed Environ Sci. 2009 Aug;22(4):345-7. doi: 10.1016/S0895-3988(09)60066-0.
To study the carbon tetrachloride-induced hepatoprotective activity in cow urine.
Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Silymarin (100 mg/kg, p.o) on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations.
The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner (P < 0.05) as sylimarin.
The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.
研究牛尿对四氯化碳诱导的肝保护活性。
用牛尿馏分研究了四氯化碳（CCl4）中毒大鼠体内的肝功能。用橄榄油（5 mL/kg，ip）中的 CCl4 与橄榄油 1:1（v/v）混合物诱导肝毒性。用牛尿馏分（三种剂量水平）和标准药物水飞蓟素（100 mg/kg，po）研究对中毒大鼠肝功能的保护作用。研究中的参数包括肝功能检查和组织学观察。
牛尿馏分以剂量依赖性方式降低 SGOT、SGPT、ALP、GGT 和总胆红素的水平（P<0.05），与水飞蓟素的作用相似。
牛尿馏分对肝功能的观察到的保护作用可能归因于牛尿中的抗氧化剂的存在。
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