Mawatari Hironori, Inamori Masahiko, Fujita Koji, Yoneda Masato, Iida Hiroshi, Endo Hiroki, Hosono Kunihiro, Nozaki Yuichi, Yoneda Kyoko, Akiyama Tomoyuki, Takahashi Hirokazu, Goto Ayumu, Abe Yasunobu, Kirikoshi Hiroyuki, Kobayashi Noritoshi, Kubota Kensuke, Saito Satoru, Nakajima Atsushi
Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan.
Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1436-8.
BACKGROUND/AIMS: Hepatic mitochondrial beta-oxidation is considered to play a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine whether there were differences between patients with NASH and healthy controls in a breath test with 13C-octanoate, a medium-chain fatty acid.
The subjects were 8 patients (5 men, 3 women, median age 46.5 years) with histologically proven NASH and 6 healthy controls (5 men, 1 women, and median age 27.8 years). The 13C breath test was performed for 4 hours using the BreathID system with a 100 mL of water containing 100 mg 13C-octanoate.
There were no significant differences between NASH patients and controls about all breath test parameters.
NASH-mediated changes in breath test parameters after ingestion of 13C-octanoate were not observed in our study. The present study findings suggest the possible preservation of 13C-octanoate metabolism (mitochondrial beta-oxidation) in patients with NASH.
背景/目的：肝线粒体β氧化被认为在非酒精性脂肪性肝炎（NASH）的发病机制中起关键作用。本研究的目的是确定NASH患者与健康对照者在使用中链脂肪酸13C-辛酸进行的呼气试验中是否存在差异。
研究对象为8例经组织学证实为NASH的患者（5例男性，3例女性，中位年龄46.5岁）和6例健康对照者（5例男性，1例女性，中位年龄27.8岁）。使用BreathID系统，以含有100mg 13C-辛酸的100mL水进行4小时的13C呼气试验。
NASH患者与对照者在所有呼气试验参数方面均无显著差异。
在我们的研究中未观察到摄入13C-辛酸后NASH介导的呼气试验参数变化。本研究结果提示NASH患者可能保留了13C-辛酸代谢（线粒体β氧化）。
