Kiliç Esra, Sahin Murat, Sahin Sedef, Ozer Sema
Pediatric Cardiology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2009 Jul-Aug;51(4):387-8.
Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoring- and the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin.
异维A酸（13 - 顺式维甲酸），一种合成的维生素A衍生物，用于治疗多种皮肤病，包括重度痤疮。异维A酸可引发室性早搏（PVCs）。我们描述了一名17岁男孩，他在接受异维A酸（罗可坦，罗氏公司）治疗面部结节性痤疮期间，心电图显示有室性早搏。心电图和动态心电图监测记录到室性早搏的存在，且治疗停止后这些室性早搏消失，这强烈提示在我们的病例中室性早搏与异维A酸有关。由于我们发现了异维A酸与记录到的室性早搏之间存在时间关联，所以在我们的病例中不能排除异维A酸对心室节律的影响。因此，临床医生应意识到异维A酸可能有致心律失常作用。
