Alan Sevil, Ünal Betül, Yildirim Aytül
Akdeniz University School of Medicine - Antalya, Turkey.
An Bras Dermatol. 2016 Nov-Dec;91(6):820-821. doi: 10.1590/abd1806-4841.20165138.
Isotretinoin has been considered a unique drug for acne treatment. However, it is associated with numerous adverse effects. Isotretinoin can trigger premature ventricular contractions. This report describes a 33-year-old-woman who presented with palpitations for 1 week while undergoing 1-month isotretinoin treatment for mild-moderate facial acne. An electrocardiogram and Holter monitoring showed premature ventricular contractions during isotretinoin (Roaccutane, Roche) treatment. Isotretinoin-related premature ventricular contractions were strongly suggested in this case due to the existence of documented premature ventricular contractions on electrocardiograms and the disappearance of these premature ventricular contractions two weeks after termination of the treatment To the authors' knowledge, there has been 1 reported case of premature ventricular contractions linked to isotretinoin use; this report describes a second such case.
异维A酸一直被认为是治疗痤疮的一种独特药物。然而，它会引发众多不良反应。异维A酸可引发室性早搏。本报告描述了一名33岁女性，她在接受为期1个月的异维A酸治疗轻度至中度面部痤疮期间出现心悸1周。心电图和动态心电图监测显示在异维A酸（罗可坦，罗氏公司）治疗期间出现室性早搏。由于心电图记录到室性早搏且在治疗终止两周后这些室性早搏消失，因此强烈提示该病例为异维A酸相关的室性早搏。据作者所知，此前有1例报告称室性早搏与使用异维A酸有关；本报告描述了第二例此类病例。
