Yeung Andrea H, Sughrue Michael E, Kane Ari J, Tihan Tarik, Cheung Steven W, Parsa Andrew T
Departments of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Neurosurg Focus. 2009 Dec;27(6):E2. doi: 10.3171/2009.9.FOCUS09185.
Vestibular schwannomas (VS) are benign tumors arising from the Schwann cells of cranial nerve VIII. Historically the prevailing therapy for patients with VS has been microsurgical resection. More recently, stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy have gained acceptance as effective alternatives. Although the side effect profile and rates of tumor control appear to be favorable for SRS, there is a subset of radioresistant tumors that continue to progress despite properly administered radiation treatment. In this review, the authors summarize what is known about the mechanism of radioresistance in VS at the clinical and molecular level. An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors.
前庭神经鞘瘤（VS）是起源于第八对颅神经施万细胞的良性肿瘤。从历史上看，VS患者的主要治疗方法是显微手术切除。最近，立体定向放射外科（SRS）和分次立体定向放射治疗已被公认为有效的替代方法。尽管SRS的副作用和肿瘤控制率似乎较好，但仍有一部分抗辐射肿瘤，尽管进行了适当的放射治疗，仍会继续进展。在这篇综述中，作者总结了在临床和分子水平上关于VS抗辐射机制的已知情况。对VS放射生物学行为的更好理解可能有助于指导SRS的合适患者选择，并可能有助于设计治疗抗辐射肿瘤的新疗法。
