IQUIMEFA: Institute of Chemical and Metabolism of Drugs, Buenos Aires, Argentina.
Immunopharmacol Immunotoxicol. 2009;31(1):130-9. doi: 10.1080/08923970802520701.
BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H2O2 was related to the activation of the ERK and P38 pathway, NO production and apoptosis. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Drugs capable of producing an increase in H2O2 levels could be used in cancer.
BW 5147（鼠淋巴瘤细胞系）。我们分析了 H2O2 在细胞增殖试验中一氧化氮和细胞凋亡的影响。分析了参与 H2O2 水平调节的酶，如超氧化物歧化酶（SOD）和过氧化物酶（PER）。H2O2 表现出双相作用。H2O2 的抑制作用与 ERK 和 P38 途径的激活、NO 产生和细胞凋亡有关。高增殖与低 H2O2 水平相关，与低 SOD 和高 PER 活性有关。能够增加 H2O2 水平的药物可用于癌症治疗。
