IQUIMEFA (UBA-CONICET), School of Pharmacy and Biochemistry, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
Cancer Invest. 2010 Jan;28(1):13-22. doi: 10.3109/07357900902849665.
Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-kappa B translocation, H2O2 production, H2O2 scavenging activity, and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+-SOD, increasing H2O2, which was implicated in the antiproliferative mechanism by the increase of Nitric oxide (NO). New drugs, which can increase H2O2, could be a therapeutic strategy for the treatment of cancer.
裂叶荆芥是一种在阿根廷使用的植物。本研究旨在分析 H2O2 在裂叶荆芥对 BW5147 细胞的抗增殖作用中的参与。进行了不同的研究：增殖、活力、亚硝酸盐产生、凋亡、氧还原活性、NF-κB 易位、H2O2 产生、H2O2 清除活性以及对外源超氧化物歧化酶的影响。提取物通过 P-38 和 ERK 途径降低增殖并诱导凋亡。提取物激活 Mn2+-SOD，增加 H2O2，这通过增加一氧化氮（NO）参与了抗增殖机制。可以增加 H2O2 的新药可能是治疗癌症的一种治疗策略。
