Department of Neurology, Himalayan Institute, Doiwala, Dehradun, India.
Acta Neurol Scand. 2010 Mar;121(3):204-8. doi: 10.1111/j.1600-0404.2009.01180.x. Epub 2009 Nov 26.
To find out natural course of solitary cerebral cysticercosis (SCC) cases after treating them with 2 weeks albendazole therapy.
All patients with SCC were treated with 2 weeks of albendazole therapy with follow-up radiological scan at 6 months and 2 years. The evolution of lesion was noted as complete resolution, calcification or persistent active. Antiepileptic drugs (AED) prophylaxis was given for 1 year in patients with complete resolution and for 2 years in calcified lesion, respectively. AED was continued in persistent lesion group till it became calcified or resoluted completely. One-year follow-up was done in all after stopping AED.
Among 345 cases, 226 (65.5%) had complete resolution with very low seizure relapse rate with 1 year of seizure free period on AED treatment. On the contrary, 105 (30.5%) had calcified lesion with high seizure relapse rate after stopping AED treatment with 2 years of seizure free period. Fourteen patients (4%) could not stop their antiepileptic medication at all because of active lesion.
Two-third of patients with SCC have favorable outcome with complete resolution and needs short-term AED prophylaxis and the rest one-third requires long AED treatment to prevent seizures.
了解阿苯达唑治疗 2 周后单纯性脑囊虫病（SCC）患者的自然病程。
所有 SCC 患者均接受 2 周阿苯达唑治疗，并在 6 个月和 2 年进行随访影像学扫描。病变的演变被记录为完全消退、钙化或持续活跃。完全缓解的患者分别给予 1 年和钙化病变 2 年的抗癫痫药物（AED）预防。持续病变组在病变完全钙化或消退之前继续使用 AED。所有患者在停止 AED 后均进行了 1 年的随访。
在 345 例患者中，226 例（65.5%）完全缓解，癫痫发作缓解率非常低，AED 治疗 1 年后无癫痫发作。相反，105 例（30.5%）有钙化病变，AED 治疗停止后癫痫复发率高，2 年内无癫痫发作。由于活动性病变，14 名患者（4%）根本无法停止使用抗癫痫药物。
三分之二的 SCC 患者有良好的结局，完全缓解，需要短期 AED 预防，其余三分之一需要长期 AED 治疗以预防癫痫发作。
