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TBP2是一种专门作用于雌性生殖细胞的通用转录因子。

TBP2 is a general transcription factor specialized for female germ cells.

作者信息

Müller Ferenc, Tora Làszlò

机构信息

Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

出版信息

J Biol. 2009;8(11):97. doi: 10.1186/jbiol196. Epub 2009 Nov 30.

DOI:10.1186/jbiol196
PMID:19951399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2804282/
Abstract

The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies, including one published in BMC Biology, provide mechanistic insights into how the TATA binding protein (TBP) and its vertebrate-specific paralog TBP2 (TRF3) switch function during the transition from the oocyte to the embryo. See research article http://www.biomedcentral.com/1741-7007/7/45.

摘要

核心启动子转录机制的复杂性已成为脊椎动物发育过程中使用的转录调控的一个额外层面。包括发表在《BMC生物学》上的一项研究在内的近期研究，为TATA结合蛋白（TBP）及其脊椎动物特异性旁系同源物TBP2（TRF3）在从卵母细胞到胚胎的转变过程中如何切换功能提供了机制上的见解。见研究文章http://www.biomedcentral.com/1741-7007/7/45 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdcf/2804282/d71daf92a30b/jbiol196-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdcf/2804282/d71daf92a30b/jbiol196-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdcf/2804282/d71daf92a30b/jbiol196-1.jpg

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1
TBP2 is a general transcription factor specialized for female germ cells.TBP2是一种专门作用于雌性生殖细胞的通用转录因子。
J Biol. 2009;8(11):97. doi: 10.1186/jbiol196. Epub 2009 Nov 30.
2
Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.对TATA结合蛋白2（TBP2）和TBP表达的分析表明，这两种蛋白在卵子发生和小鼠早期发育过程中的基因表达调控中发挥不同作用。
Reproduction. 2007 Jul;134(1):51-62. doi: 10.1530/REP-06-0337.
3
TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed.TRF3是一种与TATA框结合蛋白相关的因子，具有脊椎动物特异性且广泛表达。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91. doi: 10.1073/pnas.2036440100. Epub 2003 Nov 21.
4
TBP2 is a substitute for TBP in Xenopus oocyte transcription.TBP2是非洲爪蟾卵母细胞转录中TBP的替代物。
BMC Biol. 2009 Aug 3;7:45. doi: 10.1186/1741-7007-7-45.
5
Regulated expression of TATA-binding protein-related factor 3 (TRF3) during early embryogenesis.早期胚胎发育过程中TATA结合蛋白相关因子3（TRF3）的调控表达。
Cell Res. 2006 Jul;16(7):610-21. doi: 10.1038/sj.cr.7310064.
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TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.TBP2通过调节卵母细胞中的转录和染色质凝聚，对生殖细胞发育至关重要。
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TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes.TATA 框结合蛋白相关因子 3 通过与关键中胚层基因的 TATA 框全局相互作用，驱动人胚胎干细胞的中胚层特化。
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Specialized and redundant roles of TBP and a vertebrate-specific TBP paralog in embryonic gene regulation in Xenopus.TBP和一种脊椎动物特有的TBP旁系同源物在非洲爪蟾胚胎基因调控中的特定和冗余作用。
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Switching of the core transcription machinery during myogenesis.成肌过程中核心转录机制的转换。
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TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes.TATA 框结合蛋白相关因子 3 通过与关键中胚层基因的 TATA 框全局相互作用，驱动人胚胎干细胞的中胚层特化。
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本文引用的文献

1
TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.TBP2通过调节卵母细胞中的转录和染色质凝聚，对生殖细胞发育至关重要。
Genes Dev. 2009 Sep 15;23(18):2210-23. doi: 10.1101/gad.535209.
2
Regulation of gene expression via the core promoter and the basal transcriptional machinery.通过核心启动子和基础转录机制调控基因表达。
Dev Biol. 2010 Mar 15;339(2):225-9. doi: 10.1016/j.ydbio.2009.08.009. Epub 2009 Aug 13.
3
TBP2 is a substitute for TBP in Xenopus oocyte transcription.
Diversity in TAF proteomics: consequences for cellular differentiation and migration.
TAF蛋白质组学的多样性：对细胞分化和迁移的影响。
Int J Mol Sci. 2014 Sep 19;15(9):16680-97. doi: 10.3390/ijms150916680.
4
TBP dynamics during mouse oocyte meiotic maturation and early embryo development.TBP 在小鼠卵母细胞减数分裂成熟和早期胚胎发育过程中的动态变化。
PLoS One. 2013;8(1):e55425. doi: 10.1371/journal.pone.0055425. Epub 2013 Jan 31.
5
A plant-specific transcription factor IIB-related protein, pBRP2, is involved in endosperm growth control.一种植物特异性转录因子 IIB 相关蛋白 pBRP2 参与胚乳生长调控。
PLoS One. 2011 Feb 24;6(2):e17216. doi: 10.1371/journal.pone.0017216.
TBP2是非洲爪蟾卵母细胞转录中TBP的替代物。
BMC Biol. 2009 Aug 3;7:45. doi: 10.1186/1741-7007-7-45.
4
MyoD targets TAF3/TRF3 to activate myogenin transcription.肌分化因子（MyoD）靶向TAF3/TRF3以激活肌细胞生成素转录。
Mol Cell. 2008 Oct 10;32(1):96-105. doi: 10.1016/j.molcel.2008.09.009.
5
Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3.TATA 盒结合蛋白相关因子 Trf3 启动斑马鱼造血作用。
Nature. 2007 Dec 13;450(7172):1082-5. doi: 10.1038/nature06349. Epub 2007 Nov 28.
6
Transcription strategies in terminally differentiated cells: shaken to the core.终末分化细胞中的转录策略：核心动摇
Genes Dev. 2007 Sep 1;21(17):2113-7. doi: 10.1101/gad.1598007.
7
Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.对TATA结合蛋白2（TBP2）和TBP表达的分析表明，这两种蛋白在卵子发生和小鼠早期发育过程中的基因表达调控中发挥不同作用。
Reproduction. 2007 Jul;134(1):51-62. doi: 10.1530/REP-06-0337.
8
Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.青蛙和小鼠生殖细胞中核心启动子转录因子的发育及细胞类型特异性调控
Gene Expr Patterns. 2006 Apr;6(4):409-19. doi: 10.1016/j.modgep.2005.09.005. Epub 2006 Jan 18.
9
Specialized and redundant roles of TBP and a vertebrate-specific TBP paralog in embryonic gene regulation in Xenopus.TBP和一种脊椎动物特有的TBP旁系同源物在非洲爪蟾胚胎基因调控中的特定和冗余作用。
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13525-30. doi: 10.1073/pnas.0405536101. Epub 2004 Sep 2.
10
TBP2, a vertebrate-specific member of the TBP family, is required in embryonic development of zebrafish.TBP2是TBP家族中脊椎动物特有的成员，在斑马鱼胚胎发育中是必需的。
Curr Biol. 2004 Apr 6;14(7):593-8. doi: 10.1016/j.cub.2004.03.034.