从小鼠肝脏中分离出的肽焦谷氨酸-谷氨酰胺-甘氨酸-丝氨酸-天冬酰胺，在体外可抑制大鼠肝癌细胞的生长。
The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.
作者信息
Paulsen J E, Sundby-Hall K, Endresen L, Rugstad H E, Reichelt K L, Elgjo K
机构信息
Department of Clinical Pharmacology, Rikshospitalet, Oslo, Norway.
出版信息
Carcinogenesis. 1991 Feb;12(2):207-10. doi: 10.1093/carcin/12.2.207.
The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation in vitro of MH1C1 cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (approximately 50%) was observed at two separate dose ranges: one at 10(-7)-10(-10) M, and one at 10(-14)-10(-15) M.
最近从小鼠肝脏中分离出的肽焦谷氨酸-谷氨酰胺-甘氨酸-丝氨酸-天冬酰胺，可抑制MH1C1细胞（一种源自莫里斯可移植肝癌的大鼠克隆株）的体外DNA合成和增殖。从小鼠肝脏中分离出的生物肽及其合成类似物均呈现钟形剂量反应曲线。在两个不同的剂量范围内观察到最大抑制率（约50%）：一个在10^(-7)-10^(-10) M，另一个在10^(-14)-10^(-15) M。
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