Sheng Youyu, Chen Lianjun, Huang Zhemin, Mu Zhanglei, Kong Jincheng, Luo Yan, Yang Qinping
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Clin Lymphoma Myeloma. 2009 Dec;9(6):455-8. doi: 10.3816/CLM.2009.n.089.
Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Histopathologic examination of the skin lesion and inguinal lymph node demonstrated granulomatous infiltration with multinucleated giant cells. Positron emission tomography (PET)/computed tomography (CT) scan was performed after acute exacerbation and exhibited slightly high fluorodeoxyglucose (FDG) distribution of skin lesions, without any evidence of abnormality in the metabolism of FDG in lymph nodes or other extralymphatic organs. Concurrent use of corticosteroid and recombinant interferon-alpha successfully controlled the disease, and posttreatment PET/CT scan confirmed the response to the therapy with decreased levels of FDG uptake. PET/CT is suggested to be helpful in the assessment of disease progression and treatment response in the management of patients with GSS.
肉芽肿性皮肤松弛症（GSS）是皮肤T细胞淋巴瘤中一种极其罕见的亚型。一名14岁男孩患有进行性浸润性红斑和斑块，这些病变逐渐演变成腋窝、腹壁前壁、双侧腹股沟区及大腿处的松弛肿物和悬垂性皮肤。对皮肤病变和腹股沟淋巴结进行组织病理学检查，显示有肉芽肿性浸润及多核巨细胞。急性加重期后进行了正电子发射断层扫描（PET）/计算机断层扫描（CT），结果显示皮肤病变处氟脱氧葡萄糖（FDG）分布略高，而淋巴结或其他淋巴外器官的FDG代谢无任何异常迹象。同时使用皮质类固醇和重组干扰素-α成功控制了病情，治疗后PET/CT扫描证实了治疗反应，FDG摄取水平降低。PET/CT被认为有助于评估GSS患者病情进展及治疗反应。
