Nomura Y, Kondo H, Yamagata J, Takenaka K
Gan. 1977 Jun;68(3):333-6.
The estrogen receptor was measured in breast cancer of two male patients. Both patients had a positive receptor content in their tumors. The dissociation constant and number of binding sites were both very similar to those in the female counterpart. In one of the patients, the number of binding sites in the metastatic lesions of the liver was similar to that in the primary site. The patient responded well to the endocrine ablation therapy with a remission period of 8 months. The estrogen receptor was found to be positive in 12 out of 14 cases of male breast cancer reported previously including the present 2 patients. Three out of 4 cases with positive receptor contnet, including the present case, responded to orchiectomy.
在两名男性乳腺癌患者中检测了雌激素受体。两名患者肿瘤中的受体含量均为阳性。解离常数和结合位点数量与女性患者的非常相似。其中一名患者肝脏转移灶中的结合位点数量与原发部位相似。该患者对内分泌消融治疗反应良好，缓解期为8个月。在先前报道的14例男性乳腺癌病例（包括本研究的2例患者）中，发现12例雌激素受体呈阳性。包括本病例在内，4例受体含量为阳性的病例中有3例对睾丸切除术有反应。
