J Toxicol Sci. 2009 Dec;34(6):687-91. doi: 10.2131/jts.34.687.
Recent studies showed that perfluorooctane sulfonate (PFOS) affects the mammalian immune system at levels reportedly found in the general human population. It has been demonstrated that exposure to immunotoxic chemicals may diminish the host resistance of animals to various pathogenic challenges and enhance mortality. Therefore, the current study was carried out to characterize the effect of a 21 day pre-administration of zero, 5, or 25 microg PFOS/kg bw/day in female B6C3F1 mice on host resistance to influenza A virus infection. At the end of PFOS exposure, body/organ weights did not significantly change whereas PFOS distribution in blood plasma, spleen, thymus and lung was dose-dependently increased. PFOS exposure in mice resulted a significant increase in emaciation and mortality in response to influenza A virus. The effective plasma concentrations in female mice were at least several fold lower than reported mean blood PFOS levels from occupationally exposed humans, and fell in the upper range of blood concentrations of PFOS in the normal human population and in a wide range of wild animals. Hence, it should be important to clarify the precise mechanism(s) for excess mortality observed in the high dose group.
最近的研究表明，全氟辛烷磺酸（PFOS）在据称在普通人群中发现的水平上影响哺乳动物的免疫系统。已经证明，暴露于免疫毒性化学物质可能会降低动物对各种病原体挑战的宿主抵抗力并增加死亡率。因此，进行了当前的研究，以表征在雌性 B6C3F1 小鼠中预先给予零、5 或 25μg PFOS/kg bw/天 21 天对宿主对甲型流感病毒感染的抵抗力的影响。在 PFOS 暴露结束时，体重/器官重量没有显着变化，而血液血浆、脾脏、胸腺和肺中的 PFOS 分布则呈剂量依赖性增加。PFOS 暴露会导致小鼠对甲型流感病毒的消瘦和死亡率显着增加。雌性小鼠的有效血浆浓度至少比职业暴露人群报告的平均血液 PFOS 水平低几个数量级，并且落在正常人群和广泛的野生动物的血液中 PFOS 浓度的较高范围内。因此，阐明在高剂量组中观察到的超额死亡率的确切机制非常重要。
