Ishino Hirokazu, Hara Yasushi, Teshima Takahiro, Tanaka Shigeki, Takekoshi Susumu, Nezu Yoshinori, Harada Yasuji, Yogo Takuya, Sako Toshinori, Koyama Hidekazu, Teramoto Akira, Osamura Robert Y, Tagawa Masahiro
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
J Vet Med Sci. 2010 Mar;72(3):343-8. doi: 10.1292/jvms.09-0348. Epub 2009 Dec 1.
An 11-year-old male mixed breed dog diagnosed with Cushing's disease and diabetes mellitus was treated by hypophysectomy. After surgery, the hypercortisolemia disappeared and the diabetes status improved. The insulin requirement to control hyperglycemia gradually decreased. At 12 weeks after surgery, there was no requirement for insulin and we suspected the diabetes was completely resolved. In the present case, diabetes mellitus seems to be secondary to Cushing's disease. In conclusion, this mixed breed dog with coexisting Cushing's disease and diabetes mellitus is the first case showing the effectiveness of hypophysectomy to treat diabetes mellitus secondary to Cushing's disease in dogs.
一只11岁的雄性混血犬被诊断患有库欣氏病和糖尿病，接受了垂体切除术治疗。术后，高皮质醇血症消失，糖尿病状况改善。控制高血糖所需的胰岛素量逐渐减少。术后12周，不再需要胰岛素，我们怀疑糖尿病已完全治愈。在本病例中，糖尿病似乎继发于库欣氏病。总之，这只同时患有库欣氏病和糖尿病的混血犬是首例显示垂体切除术对治疗犬继发性库欣氏病糖尿病有效的病例。
