Teshima Takahiro, Hara Yasushi, Taoda Takahiro, Koyama Hidekazu, Takahashi Kimimasa, Nezu Yoshinori, Harada Yasuji, Yogo Takuya, Nishida Kouji, Osamura Robert Y, Teramoto Akira, Tagawa Masahiro
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
J Vet Med Sci. 2008 May;70(5):487-91. doi: 10.1292/jvms.70.487.
Thrombosis is a potential complication of hyperadrenocorticism (HAC) in dogs. An 8-year-old male Beagle diagnosed with pituitary-dependent HAC had complicated with thrombosis in the caudal vena cava and abdominal aorta, which was treated by hypophysectomy and antithrombotic therapy. After hypophysectomy, hypercortisolemia disappeared and the general condition was also significantly improved. Ultrasonography after hypophysectomy revealed that the thrombus remained in the abdominal aorta, but the thrombus in the caudal vena cava had disappeared. However 692 days after the hypophysectomy, the dog had an acute onset of dyspnea and died. Postmortem examination revealed the presence of thrombi in the abdominal aorta and the pulmonary artery. Observations from this case show that HAC dogs must be attention to thrombosis.
血栓形成是犬肾上腺皮质功能亢进（HAC）的一种潜在并发症。一只8岁雄性比格犬被诊断为垂体依赖性HAC，并伴有尾腔静脉和腹主动脉血栓形成，通过垂体切除术和抗血栓治疗。垂体切除术后，高皮质醇血症消失，一般状况也明显改善。垂体切除术后的超声检查显示，腹主动脉中的血栓仍然存在，但尾腔静脉中的血栓已经消失。然而，垂体切除术后692天，这只狗突然出现呼吸困难并死亡。尸检发现腹主动脉和肺动脉中有血栓。该病例观察表明，患有HAC的犬必须注意血栓形成。
