UPMC Univ Paris 06, INSERM, UMR945, AP-HP, Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.
AIDS. 2010 Feb 20;24(4):614-7. doi: 10.1097/QAD.0b013e32833556f3.
The effects of a 10-year control of HIV replication without viral blips with antiretroviral therapy were examined in progressors. CD4 cell counts did not plateau but showed a continuous increase until the 10th year. Ultrasensitive techniques showed very low plasma HIV RNA and cell-associated DNA levels. Robust memory T cell responses to HIV-p24 were higher than in 3-year treated patients and comparable to those of Elite controllers, whereas interferon-gamma-producing HIV-specific T cells were infrequent. Long-term and efficient antiretroviral therapy provides continuous benefits both on the immune system and on the HIV reservoirs.
在进展者中检查了抗逆转录病毒治疗无病毒突破的 10 年 HIV 复制控制的效果。CD4 细胞计数没有达到平台期，而是持续增加，直到第 10 年。超敏技术显示血浆 HIV RNA 和细胞相关 DNA 水平非常低。针对 HIV-p24 的强大记忆 T 细胞反应高于治疗 3 年的患者，与精英控制器相当，而产生干扰素-γ的 HIV 特异性 T 细胞则很少见。长期有效的抗逆转录病毒治疗对免疫系统和 HIV 储存库都有持续的益处。
