International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, ul. Polabska 4, Szczecin 70-115, Poland.
Eur J Cancer Prev. 2010 Mar;19(2):167-71. doi: 10.1097/CEJ.0b013e32832945c3.
Several recent association studies implicate three neighbouring regions of chromosome 8q24 as the site of prostate cancer susceptibility loci. One region contains both a microsatellite marker DG8S737 and a single nucleotide polymorphism rs1447295. Both have been consistently associated with prostate cancer risk in several populations. However, studies to date have not inquired whether the susceptibility associated with this particular region of 8q24 extends to other cancer sites. We genotyped 3822 cases of cancer of various sites and 1807 controls for rs1447295 polymorphism. A positive association was seen for prostate cancer, but not for any of the other sites studied [odds ratios (ORs) ranging from 0.8 to 1.1]. Prostate cancer cases and controls were genotyped for both rs1447285 and DG8S737. Significant ORs were observed for the A allele of rs1447285 (OR = 1.4; P = 0.01) and the -8 allele of DG8S737 (OR = 1.6; P = 0.006). The association was particularly strong for men with familial prostate cancer (OR = 2.0, P = 0.004 for the A allele; OR = 3.5, P<0.0001 for the -8 allele). The OR associated with the A allele of rs1447295 was slightly higher for aggressive tumours (Gleason score 8 or more) (OR = 1.5), than for tumours with Gleason score 7 and below (OR = 1.3). In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere. Although the carcinogenic mechanism associated with this particular locus of 8q24 is unclear it appears to be specific to prostate cancer.
几项最近的关联研究表明，8 号染色体 q24 上的三个相邻区域是前列腺癌易感位点的所在位置。其中一个区域包含微卫星标记 DG8S737 和单核苷酸多态性 rs1447295。这两个标记在多个人群中都与前列腺癌风险持续相关。然而，迄今为止的研究尚未探究 8q24 这一特定区域的易感性是否扩展到其他癌症部位。我们对 3822 例各种部位的癌症病例和 1807 例对照进行了 rs1447295 多态性的基因分型。我们发现，该多态性与前列腺癌呈正相关，但与研究的其他部位无关[比值比（ORs）范围从 0.8 到 1.1]。我们对前列腺癌病例和对照进行了 rs1447285 和 DG8S737 的双重基因分型。我们观察到 rs1447285 的 A 等位基因（OR = 1.4；P = 0.01）和 DG8S737 的-8 等位基因（OR = 1.6；P = 0.006）存在显著的 OR。这种关联在家族性前列腺癌患者中尤为明显（A 等位基因的 OR = 2.0，P = 0.004；-8 等位基因的 OR = 3.5，P<0.0001）。与 rs1447295 的 A 等位基因相关的 OR 在侵袭性肿瘤（Gleason 评分 8 或更高）（OR = 1.5）中略高于 Gleason 评分 7 及以下的肿瘤（OR = 1.3）。总之，在波兰人群中，8q24 上 rs1447295 和 DG8S737 多态性与前列腺癌风险之间的关系与在其他地方观察到的关系相似。虽然与 8q24 这一特定位置相关的致癌机制尚不清楚，但它似乎是前列腺癌特有的。
