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rs1447295基因多态性与前列腺癌易感性关联的Meta分析。

Meta-analysis of association between rs1447295 polymorphism and prostate cancer susceptibility.

作者信息

Zhou Juan, Yu Yang, Zhu Anyou, Wang Fengchao, Kang Shuxia, Pei Yunfeng, Cao Chunping, Ding Chen, Wang Duping, Sun Li, Niu Guoping

机构信息

Department of Clinical Laboratory, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People's Republic of China.

Department of Medical Oncology, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People's Republic of China.

出版信息

Oncotarget. 2017 May 5;8(40):67029-67042. doi: 10.18632/oncotarget.17627. eCollection 2017 Sep 15.

DOI:10.18632/oncotarget.17627
PMID:28978014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5620154/
Abstract

AIMS

A number of studies have found that the single nucleotide polymorphisms (SNPs) within the 8q24 region of genome were associated with the susceptibility of prostate cancer. Association between 8q24 SNP variant rs1447295 and higher risk of prostate cancer had been investigated, but those studies were incomplete and the conclusions were obscure.

METHODS

To better elucidate the relationship between rs1447295 polymorphism and the susceptibility of prostate cancer, we performed a more comprehensive meta-analysis about the association between rs1447295 polymorphism and prostate cancer susceptibility by collecting relevant articles published up to November, 2016 and excluding many replicated cohort data existing in previous reports, which made the conclusion more reliant and objective.

RESULTS

The results showed that there was a significant prostate cancer risk associated with rs1447295 polymorphism not only in the total groups, but also in American, European and Asian descent subgroups. Meanwhile, a comprehensive analysis about the association between rs1447295 polymorphism and prostate cancer risk were conducted by using different clinical characteristic stratifications including Gleason score, tumor stage and PSA level. The result showed that rs1447295 polymorphism was correlated with different stages of prostate cancer.

CONCLUSIONS

There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.

摘要

目的

多项研究发现，基因组8q24区域内的单核苷酸多态性（SNP）与前列腺癌易感性相关。已对8q24 SNP变异体rs1447295与前列腺癌高风险之间的关联进行了研究，但这些研究并不完整，结论也不明确。

方法

为了更好地阐明rs1447295多态性与前列腺癌易感性之间的关系，我们通过收集截至2016年11月发表的相关文章，并排除先前报告中存在的许多重复队列数据，对rs1447295多态性与前列腺癌易感性之间的关联进行了更全面的荟萃分析，这使得结论更具可靠性和客观性。

结果

结果表明，rs1447295多态性不仅在总体组中，而且在美国、欧洲和亚洲血统亚组中均与前列腺癌风险显著相关。同时，利用包括Gleason评分、肿瘤分期和PSA水平在内的不同临床特征分层，对rs1447295多态性与前列腺癌风险之间的关联进行了综合分析。结果表明，rs1447295多态性与前列腺癌的不同分期相关。

结论

rs1447295多态性与不同种族和不同前列腺癌分期的前列腺癌易感性之间存在密切关联，提示rs1447295可能作为前列腺癌诊断的可靠生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/f41505372c7c/oncotarget-08-67029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/580661c62c94/oncotarget-08-67029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/e6ea3f0a48e3/oncotarget-08-67029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/bcf9e8fede82/oncotarget-08-67029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/f5ebf9846453/oncotarget-08-67029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/6b63342b24d0/oncotarget-08-67029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/1731486b9c74/oncotarget-08-67029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/82d3042b6aef/oncotarget-08-67029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/71418cf2cfba/oncotarget-08-67029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/f41505372c7c/oncotarget-08-67029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/580661c62c94/oncotarget-08-67029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/e6ea3f0a48e3/oncotarget-08-67029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/bcf9e8fede82/oncotarget-08-67029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/f5ebf9846453/oncotarget-08-67029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/6b63342b24d0/oncotarget-08-67029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/1731486b9c74/oncotarget-08-67029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/82d3042b6aef/oncotarget-08-67029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/71418cf2cfba/oncotarget-08-67029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41b/5620154/f41505372c7c/oncotarget-08-67029-g009.jpg

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