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Thiopurine pathway.硫嘌呤代谢途径。
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2
Methylated and non methylated thiopurine nucleotide ratio (Me6-MPN/6-TGN): usefulness in the monitoring of azathioprine therapy?甲基化与非甲基化硫嘌呤核苷酸比率（Me6-MPN/6-TGN）：在硫唑嘌呤治疗监测中的作用？
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Application of pharmacogenetics to optimization of mercaptopurine dosing.药物遗传学在优化巯嘌呤剂量中的应用。
J Natl Cancer Inst. 1999 Dec 1;91(23):1983-5. doi: 10.1093/jnci/91.23.1983.
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The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens.在单剂量和多剂量给药方案后，谷胱甘肽激活的硫嘌呤前药反式-6-(2-乙酰乙烯硫基)鸟嘌呤和顺式-6-(2-乙酰乙烯硫基)嘌呤比6-硫鸟嘌呤引起的体内毒性更小。
Mol Cancer Ther. 2002 Nov;1(13):1211-20.
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Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.两兄弟溃疡性结肠炎巯嘌呤代谢异常，经别嘌醇和巯嘌呤剂量减少治疗后成功缓解。
Dig Dis Sci. 2012 Jan;57(1):250-3. doi: 10.1007/s10620-011-1999-x. Epub 2011 Dec 7.
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Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization.基于模型的化疗药物个体化治疗：贝叶斯群体建模与剂量优化。
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7
Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes.在儿童急性淋巴细胞白血病维持治疗期间6-硫鸟嘌呤核苷酸掺入DNA中——硫嘌呤甲基转移酶基因型的影响
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8
Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.硫嘌呤甲基转移酶和硫嘌呤代谢物分析在炎症性肠病患者临床实践中的应用价值。
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Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.抗癌和免疫抑制硫唑嘌呤类药物巯嘌呤和硫唑嘌呤的药物基因组学研究。
Br J Clin Pharmacol. 2008 Oct;66(4):517-28. doi: 10.1111/j.1365-2125.2008.03248.x. Epub 2008 Jun 28.
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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.巯嘌呤治疗不耐受与硫嘌呤S-甲基转移酶基因位点的杂合性
J Natl Cancer Inst. 1999 Dec 1;91(23):2001-8. doi: 10.1093/jnci/91.23.2001.

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Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy.急性淋巴细胞白血病中的药物遗传学：为个性化硫嘌呤治疗整合进展
Med Sci (Basel). 2025 Aug 5;13(3):112. doi: 10.3390/medsci13030112.
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Compatibility of Post-Kidney Transplant Immunosuppression Therapy with Lactation.肾移植后免疫抑制治疗与哺乳的兼容性。
J Clin Med. 2025 Mar 29;14(7):2364. doi: 10.3390/jcm14072364.
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Frequency of pharmacogenomic variants affecting safety and efficacy of immunomodulators and biologics in a South Asian population from Sri Lanka.斯里兰卡南亚人群中影响免疫调节剂和生物制剂安全性和疗效的药物基因组学变异的频率。
Hum Genomics. 2024 Sep 27;18(1):107. doi: 10.1186/s40246-024-00674-w.
4
Innovating Thiopurine Therapeutic Drug Monitoring: A Systematic Review and Meta-Analysis on DNA-Thioguanine Nucleotides (DNA-TG) as an Inclusive Biomarker in Thiopurine Therapy.创新硫嘌呤治疗药物监测：以 DNA-硫鸟嘌呤核苷酸 (DNA-TG) 为包容性生物标志物的硫嘌呤治疗的系统评价和荟萃分析。
Clin Pharmacokinet. 2024 Aug;63(8):1089-1109. doi: 10.1007/s40262-024-01393-0. Epub 2024 Jul 20.
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Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).采用液相色谱-串联质谱法（LC-MS/MS）对人红细胞中的硫嘌呤代谢物进行定量分析。
Methods Mol Biol. 2024;2737:443-452. doi: 10.1007/978-1-0716-3541-4_41.
6
The Effectiveness and Safety of First-Line Thioguanine in Thiopurine-Naïve Inflammatory Bowel Disease Patients.一线硫鸟嘌呤在硫嘌呤初治炎症性肠病患者中的疗效和安全性。
Inflamm Bowel Dis. 2024 Sep 3;30(9):1492-1499. doi: 10.1093/ibd/izad197.
7
Can Pharmacogenetic Variants in , and Genes Be Used as Potential Markers of Outcome Prediction in Systemic Sclerosis Patients?基因、基因和基因中的药物遗传学变异能否作为系统性硬化症患者预后预测的潜在标志物？
Int J Mol Sci. 2023 May 10;24(10):8538. doi: 10.3390/ijms24108538.
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as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells.作为自噬和巯基嘌呤细胞毒性的调节剂：在淋巴和肠道细胞中的机制。
Life Sci Alliance. 2023 Jan 3;6(3). doi: 10.26508/lsa.202201610. Print 2023 Mar.
9
Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease.117 例炎症性肠病女性妊娠期间接触硫鸟嘌呤。
J Crohns Colitis. 2023 May 3;17(5):738-745. doi: 10.1093/ecco-jcc/jjac183.
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Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A Multi-Center Case Series.儿童炎症性肠病中硫鸟嘌呤的安全性：一项多中心病例系列研究。
J Pediatr Gastroenterol Nutr. 2022 Dec 1;75(6):e111-e115. doi: 10.1097/MPG.0000000000003621. Epub 2022 Sep 20.

Thiopurine pathway.

作者信息

Zaza Gianluigi, Cheok Meyling, Krynetskaia Natalia, Thorn Caroline, Stocco Gabriele, Hebert Joan M, McLeod Howard, Weinshilboum Richard M, Relling Mary V, Evans William E, Klein Teri E, Altman Russ B

机构信息

Universita' degli Studi di Bari, Bari, Italy.

出版信息

Pharmacogenet Genomics. 2010 Sep;20(9):573-4. doi: 10.1097/FPC.0b013e328334338f.

DOI:10.1097/FPC.0b013e328334338f
PMID:19952870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3098750/
Abstract
摘要