Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, USA.
J Neuroophthalmol. 2009 Dec;29(4):296-9. doi: 10.1097/WNO.0b013e3181c25390.
After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus. Brain MRI showed restricted diffusion in the rostral midbrain and temporal and parietal lobes but not in the pons. Over several weeks, all neurologic and imaging deficits resolved. This is the first report to document ocular motor abnormalities associated with midbrain dysfunction in ODS.
在迅速纠正严重低钠血症后，一名 36 岁男性出现了渗透性脱髓鞘综合征（ODS），表现为认知障碍、四肢无力、双侧第三颅神经麻痹和眼球诱发的上跳和旋转性眼球震颤。脑部 MRI 显示中脑头部、颞叶和顶叶弥散受限，但桥脑不受累。数周后，所有神经和影像学缺陷均得到解决。这是第一份报告，记录了 ODS 中与中脑功能障碍相关的眼球运动异常。
