Department of Pathology, New York University Medical Center, New York 10016, USA.
Int J Gynecol Pathol. 2010 Jan;29(1):51-4. doi: 10.1097/PGP.0b013e3181b0259b.
Nine cases of symplastic uterine leiomyomas were chosen from our files using strict criteria. An immunochemical study of the expressions of Ki-67, estrogen receptor, progesterone receptor, and p53 was performed. For each antigen, the percentages of positive atypical (bizarre) cells and nonatypical cells were compared. Both groups had identical and fairly high estrogen receptor and progesterone receptor immunohistochemical profiles and very low levels of p53 expression. The atypical cells had significantly higher percentages of cells expressing Ki-67 compared with nonatypical cells (17+/-20% vs. 3+/-3.9%). Therefore, rather than being degenerative in nature, the atypical cells are actively proliferating.
从我们的档案中选择了 9 例合胞体子宫肌瘤，使用严格的标准。对 Ki-67、雌激素受体、孕激素受体和 p53 的表达进行了免疫化学研究。对于每种抗原，比较了阳性异型（奇异）细胞和非异型细胞的百分比。两组均具有相同且相当高的雌激素受体和孕激素受体免疫组织化学特征，p53 表达水平极低。与非异型细胞相比，异型细胞中表达 Ki-67 的细胞百分比明显更高（17+/-20%比 3+/-3.9%）。因此，异型细胞不是退行性的，而是活跃增殖的。
