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壁间肌瘤患者生育力低下的潜在原因。

Potential causes of subfertility in patients with intramural fibroids.

作者信息

Pier Bruce D, Bates G Wright

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, WIC 10390, 1700 6th Avenue South, Birmingham, AL 35294 UK.

出版信息

Fertil Res Pract. 2015 Aug 25;1:12. doi: 10.1186/s40738-015-0005-2. eCollection 2015.

DOI:10.1186/s40738-015-0005-2
PMID:28620517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5424315/
Abstract

BACKGROUND

Intramural leiomyomas have been long debated as a potential cause of infertility and pregnancy loss.

FINDINGS

Previous research has linked intramural fibroids to defective implantation, as well as to abnormal peristaltic events of the uterine smooth muscle. Previous reports describe the effects of intramural fibroids on normal human fertility and early pregnancy loss, specifically in regards to implantation failure.

CONCLUSION

A thorough understanding of prior research may direct new research focus, leading to better understanding of leiomyoma-associated infertility.

摘要

背景

壁间平滑肌瘤一直被视为不孕症和流产的潜在原因，备受争议。

研究结果

先前的研究已将壁间肌瘤与植入缺陷以及子宫平滑肌异常蠕动事件联系起来。先前的报告描述了壁间肌瘤对正常人类生育能力和早期流产的影响，特别是在植入失败方面。

结论

对先前研究的透彻理解可能会引导新的研究重点，从而更好地理解与平滑肌瘤相关的不孕症。

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本文引用的文献

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A combined ultrasound and histologic approach for analysis of uterine fibroid pseudocapsule thickness.联合超声和组织学方法分析子宫肌瘤假包膜厚度。
Reprod Sci. 2014 Sep;21(9):1177-86. doi: 10.1177/1933719114537719. Epub 2014 May 30.
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Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window.壁间子宫肌瘤切除术对种植窗期子宫内膜HOXA10和HOXA11 mRNA表达的影响。
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3 T MRI uterine peristalsis: comparison of symptomatic fibroid patients versus controls.
生殖生理学 - ？
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Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment.宫腔内非瘤腔变形型平滑肌瘤对体外受精治疗单活产胎盘组织病理学及围产结局的影响。
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Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window.子宫肌瘤切除术对种植窗期子宫内膜谷胱甘肽过氧化物酶3（GPx3）和糖蛋白15（glycodelin）mRNA表达的影响。
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Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment: a retrospective cohort study.子宫肌瘤不影响子宫内膜腔对体外受精治疗结局的影响：一项回顾性队列研究。
Fertil Steril. 2014 Mar;101(3):716-21. doi: 10.1016/j.fertnstert.2013.11.023. Epub 2014 Jan 11.
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Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction.子宫肌瘤：发病机制及其与子宫内膜和内膜肌层交界处的相互作用
Obstet Gynecol Int. 2013;2013:173184. doi: 10.1155/2013/173184. Epub 2013 Sep 12.
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The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.子宫纤维瘤假包膜中的阿片类神经肽：与人类生殖中宫颈完整性的潜在关联。
Gynecol Endocrinol. 2013 Nov;29(11):982-8. doi: 10.3109/09513590.2013.824958. Epub 2013 Aug 12.
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Uterine leiomyomas: effects on architectural, cellular, and molecular determinants of endometrial receptivity.子宫平滑肌瘤：对子宫内膜容受性的结构、细胞和分子决定因素的影响。
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Surgical treatment of fibroids for subfertility.子宫肌瘤的手术治疗与不孕症
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