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[4岁以上儿童哮喘管理的调整时机与方式]

[When and how to modify the management of asthma in children over the age of 4].

作者信息

de Blic J, Deschildre A, Pin I, Dubus J-C

机构信息

Service de Pneumologie et Allergologie pédiatriques, Hôpital Necker Enfants Malades, Paris, France.

出版信息

Rev Mal Respir. 2009 Oct;26(8):827-35. doi: 10.1016/s0761-8425(09)73678-2.

Abstract

The treatment of asthma in children should not be fixed but rather must be regularly adapted to keep the condition under control defined according to clinical and functional criteria. In a child whose asthma is controlled, a step down in therapy should be carried out every 3 to 6 months to achieve the minimal effective level of treatment. In a child whose asthma appears not to be controlled, it is necessary initially to evaluate compliance with therapy and to seek aggravating factors which may include allergic rhinitis, multiple sensitisation, tobacco exposure, psychological factors, obesity, gastro- oesophageal reflux and infection. Where control of asthma is poor the main therapeutic strategy rests on an increase in the dose of inhaled corticosteroid and on the addition of other anti-asthmatic treatments--inhaled long--acting beta 2 agonists and oral leukotriene antagonists.

摘要

儿童哮喘的治疗不应一成不变,而必须定期调整,以根据临床和功能标准将病情控制在规定范围内。对于哮喘得到控制的儿童,应每3至6个月逐步减少治疗,以达到最低有效治疗水平。对于哮喘似乎未得到控制的儿童,首先有必要评估其对治疗的依从性,并寻找可能的加重因素,这些因素可能包括过敏性鼻炎、多重致敏、接触烟草、心理因素、肥胖、胃食管反流和感染。如果哮喘控制不佳,主要的治疗策略是增加吸入性皮质类固醇的剂量,并添加其他抗哮喘治疗药物——吸入长效β2激动剂和口服白三烯拮抗剂。

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