Department of Dietetics, Nutrition, Harokopio University, Athens, Greece.
Eur J Clin Nutr. 2010 Mar;64(3):253-8. doi: 10.1038/ejcn.2009.124. Epub 2009 Dec 2.
BACKGROUND/OBJECTIVES: Height is a classic polygenic trait, with a number of genes underlying its variation. We evaluated the prospect of gene-to-diet interactions in a children's cohort, for the insulin-like growth factor II (IGF) rs680 polymorphism and height variation.
SUBJECTS/METHODS: We screened 795 periadolescent children (424 girls) aged 10-11 years old from the Gene and Diet Attica Investigation (GENDAI) pediatric cohort for the IGF rs680 polymorphism (rs680).
Children homozygous for the common allele (GG) were taller (148.9+/-7.9 cm) compared with those with the A allele (148.1+/-7.9 cm), after adjusting for age, sex and dairy intake (beta+/-s.e.: 2.1+/-0.95, P=0.026). A trend for rs680 x dairy intake interaction was also revealed (P=0.09). Stratification by IGF rs680 genotype revealed positive significant (P=0.014) association between dairy product intake and height in A-allele children adjusted for the same confounders. A daily increase of four dairy servings was associated with a 0.4 cm increase in height. On grouping dairy intake into low (1.9+/-0.7 servings per day) and high dairy product consumption (4.4+/-1.5 servings per day), children with the A allele who were high dairy product consumers were taller compared with the low dairy product consumers (148.8+/-7.9 vs 147.4+/-7.7 cm, respectively, P=0.05).
A higher consumption of dairy products is associated with increased height depending on the rs680 IGF2 genotype.
背景/目的：身高是一个经典的多基因特征，有许多基因影响其变化。我们评估了儿童队列中基因与饮食相互作用的前景，以胰岛素样生长因子 II (IGF) rs680 多态性和身高变化为研究对象。
受试者/方法：我们从 Gene and Diet Attica Investigation (GENDAI) 儿科队列中筛选了 795 名 10-11 岁的青春期前儿童（424 名女孩），对 IGF rs680 多态性（rs680）进行了筛查。
在调整年龄、性别和乳制品摄入量后，与携带 A 等位基因的儿童（148.1+/-7.9cm）相比，常见等位基因（GG）纯合子的儿童更高（148.9+/-7.9cm）（β+/-标准误：2.1+/-0.95，P=0.026）。还揭示了 rs680 x 乳制品摄入量的交互作用趋势（P=0.09）。根据 IGF rs680 基因型进行分层，在调整相同混杂因素后，A 等位基因儿童的乳制品摄入量与身高呈正相关（P=0.014）。每天增加 4 份乳制品与身高增加 0.4cm 相关。将乳制品摄入量分为低（每天 1.9+/-0.7 份）和高乳制品消费（每天 4.4+/-1.5 份）两组，与低乳制品消费者相比，高乳制品消费者的 A 等位基因儿童更高（148.8+/-7.9 与 147.4+/-7.7cm，分别，P=0.05）。
根据 rs680 IGF2 基因型，较高的乳制品摄入量与身高增加有关。
