一篇批判性综述：2,3,7,8-四氯二苯并对二恶英（2,3,7,8-TCDD）对双壳贝类性腺发育的影响
A critical review: 2,3,7,8 -tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) effects on gonad development in bivalve mollusks.
作者信息
Cooper Keith R, Wintermyer Margy
机构信息
Department of Biochemistry and Microbiology, Rutgers University, School of Environmental and Biological Sciences, New Brunswick, New Jersey, USA.
出版信息
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):226-45. doi: 10.1080/10590500903310112.
Bivalve mollusks are equally sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin's (2,3,7,8-TCDD) effect on gonad development, embryonic development, and epithelial lesion occurrence as higher vertebrates. 2,3,7,8-TCDD alters normal development of reproductive organs and early development in bivalve mollusks at 2 to 20 pg/g wet weight. In both Crassostria virginica and Mya arenaria, 2,3,7,8-TCDD preferentially accumulates into the gonads. The sensitivity of gonad maturation is likely due to disruption of cross-talk between highly conserved steroid, insulin, and metabolic pathways involved in gonad differentiation. The altered gonad development and decreased veliger larval survival can partially explain the lack of self-sustaining bivalve populations in 2,3,7,8-TCDD contaminated estuaries.
双壳贝类软体动物对2,3,7,8-四氯二苯并对二恶英（2,3,7,8-TCDD）对性腺发育、胚胎发育以及上皮病变发生的影响与高等脊椎动物同样敏感。2,3,7,8-TCDD在湿重2至20皮克/克时会改变双壳贝类软体动物生殖器官的正常发育和早期发育。在弗吉尼亚牡蛎和砂海螂中，2,3,7,8-TCDD都优先在性腺中积累。性腺成熟的敏感性可能是由于参与性腺分化的高度保守的类固醇、胰岛素和代谢途径之间的相互作用受到破坏。性腺发育改变和担轮幼虫存活率降低可以部分解释在受2,3,7,8-TCDD污染的河口缺乏自我维持的双壳贝类种群的原因。
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