Division of General Surgery A, Department of Surgery, University of Verona Medical School, 37134 Verona, Italy.
J Surg Oncol. 2010 Feb 1;101(2):111-5. doi: 10.1002/jso.21452.
Cholangiocarcinoma can be classified as intrahepatic (ICC) or perihilar (PCC). The objectives of this study is to evaluate the surgical outcomes of patients with PCC and ICC, identify the main prognostic factors related to survival and compare the outcome and the prognostic factors of PCC and ICC.
Ninety-five out of 152 patients observed between January 1990 and December 2007 at Surgical Division of University of Verona Medical School underwent the resection of ICC (33 patients) or PCC (62 patients).
Overall median survival was 24 months with a 3- and 5-year survival rate of 45% and 23%, respectively. Prognostic factors for survival were macroscopic types of the tumor, the resection of extrahepatic bile duct, radical resection, lymph node metastases, and macro-vascular invasion. Survival was related with the macroscopic type of the tumors with a 5-year survival rate of 26% and 13% for ICC and PCC, respectively. Univariate analysis identified that negative clinico-pathological factors where significant more frequently found in PCC compared to ICC.
We identified that ICC have longer survival rate compared to PCC. PCC showed a higher frequency of negative clinico-pathological factors such as non-radical (R+) resection, perineural infiltration and macro-vascular invasion.
胆管癌可分为肝内型（ICC）或肝门周围型（PCC）。本研究旨在评估 PCC 和 ICC 患者的手术结果，确定与生存相关的主要预后因素，并比较 PCC 和 ICC 的结果和预后因素。
1990 年 1 月至 2007 年 12 月，在维罗纳大学医学院外科部观察到的 152 名患者中有 95 名接受了 ICC（33 名患者）或 PCC（62 名患者）切除术。
总体中位生存期为 24 个月，3 年和 5 年生存率分别为 45%和 23%。生存的预后因素包括肿瘤的大体类型、肝外胆管切除、根治性切除、淋巴结转移和大血管侵犯。生存与肿瘤的大体类型有关，ICC 和 PCC 的 5 年生存率分别为 26%和 13%。单因素分析表明，与 ICC 相比，PCC 中阴性临床病理因素更为常见。
我们发现 ICC 的生存率高于 PCC。PCC 显示出更高频率的阴性临床病理因素，如非根治性（R+）切除、神经周围浸润和大血管侵犯。
