Zhao Fei-fan, Wang Jia-ling, Wu Wen-ming, Huang De-liang, Dai Pu, Yang Shi-ming, Han Wei-ju, Han Dong-yi
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of People's Liberation Army, Beijing 100853, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;44(6):444-8.
To explore methods of treatment for adenoid cystic carcinoma of external auditory canal, and discuss the correlating factors that effect prognosis.
A retrospective analysis of 19 cases of adenoid cystic carcinoma of external auditory canal treated from 1988 to 2004 was carried out. Based on University of Pittsburgh TNM staging system of external auditory canal carcinoma, 19 cases were classified into groups as 5 cases in T1, 2 in T2, 6 in T3, and 6 in T4. Local resection was performed in cases in stage T1 and T2, while radical mastoidectomy or temporal bone resection was performed in stage T3 and T4. Radiotherapy was applied after operation. Relapsed cases with isolated metastasis were treated by surgery. Multiple metastasis were treated with radiotherapy.
The follow-up time is from 6 months to 19 years, and the median is 44 months. There're 8 cases with more than 5 years' follow-up. Twelve patients relapsed and 7 had metastasis but 4 died. The cases with positive incisal edge after first operation relapsed even treated with radiotherapy. In recurrent cases, 9 cases received more than 2 operations, 8 more than 3, and 4 received 4 operations.
The adenoid cystic carcinoma of external auditory canal grows insidiously, and relapses frequently. But the patients can live long with neoplasm implanted. A wide surgical excision combined with post operative radiotherapy was proposed, and negative incision edge should be confirmed. Recurrent cases can be treated with several operations to elongate survival. Multiple relapses will cause metastasis more frequently. Metastasis is the main reason to cause death.
探讨外耳道腺样囊性癌的治疗方法,并讨论影响预后的相关因素。
对1988年至2004年收治的19例外耳道腺样囊性癌患者进行回顾性分析。根据匹兹堡大学外耳道癌TNM分期系统,将19例患者分为T1期5例、T2期2例、T3期6例、T4期6例。T1期和T2期患者行局部切除术,T3期和T4期患者行根治性乳突切除术或颞骨切除术。术后进行放疗。孤立转移的复发病例采用手术治疗。多发转移病例采用放疗。
随访时间6个月至19年,中位时间为44个月。有8例患者随访时间超过5年。12例患者复发,7例发生转移,但4例死亡。首次手术后切缘阳性的病例即使接受放疗仍复发。复发病例中,9例接受了2次以上手术,8例接受了3次以上手术,4例接受了4次手术。
外耳道腺样囊性癌生长隐匿,复发频繁。但患者带瘤生存时间较长。建议行广泛手术切除并结合术后放疗,且应确保切缘阴性。复发病例可通过多次手术延长生存期。多次复发更易导致转移。转移是导致死亡的主要原因。