20例骨髓肉芽肿的临床分析
[A clinical analysis of 20 cases with bone marrow granulomas].
作者信息
Feng Jun, Zhang Hong, Zhong Ding-Rong
机构信息
Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Zhonghua Nei Ke Za Zhi. 2009 Jun;48(6):485-7.
OBJECTIVE
To study the clinical feature and original diseases of bone marrow granulomas.
METHODS
A total of 5217 bone marrow biopsies were retrospectively analyzed in Peking Union Medical College Hospital from January 2001 to December 2007.
RESULTS
Bone marrow granulomas were present in 20 cases, representing an incidence of 0.38% in the series and an annual incidence of 2.9 cases per year. Finally, 13 of these cases (65%) were diagnosed with tuberculosis. Hematological neoplasms and viral hepatitis were found in 4 and 2 cases respectively. Acute interstitial nephritis was diagnosed in one case.
CONCLUSIONS
The finding of a granuloma in a bone marrow biopsy is not common and unspecific. Tuberculosis, hematological neoplasms and viral hepatitis are the most common underlying diseases. Bone marrow biopsy is an important method for the diagnosis of disseminated tuberculosis.
目的
研究骨髓肉芽肿的临床特征及原发病。
方法
回顾性分析北京协和医院2001年1月至2007年12月期间共5217例骨髓活检病例。
结果
20例存在骨髓肉芽肿，占该系列病例的0.38%，年发病率为每年2.9例。最终，其中13例（65%）被诊断为结核病。血液系统肿瘤和病毒性肝炎分别见于4例和2例。1例诊断为急性间质性肾炎。
结论
骨髓活检中发现肉芽肿并不常见且缺乏特异性。结核病、血液系统肿瘤和病毒性肝炎是最常见的基础疾病。骨髓活检是诊断播散性结核病的重要方法。
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