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肺外结核的不寻常表现。

Unusual manifestation of extrapulmonary tuberculosis.

作者信息

Alghamdi Aisha A, Awan Faiza S, Maniyar Iqbal H, Alghamdi Naif A

机构信息

Medical Department, King Abdulaziz University Hospital (KAUH), P.O. Box 80200, Jeddah 21589, Saudi Arabia.

出版信息

Case Rep Med. 2013;2013:353798. doi: 10.1155/2013/353798. Epub 2013 Apr 28.

DOI:10.1155/2013/353798
PMID:23710189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3655508/
Abstract

Though commonly encountered, extrapulmonary tuberculosis (TB) can sometimes present with variable clinical picture intricating the diagnosis (Avasthi et al., 2010). The nonspecific symptoms include pyrexia of unknown origin, hepatosplenomegaly, lymphadenopathy, meningitis, and, rarely, variety of hematological abnormalities, namely, anemia, pancytopenia, and leukemoid reaction (Avasthi et al., 2010). When it presents with bone marrow (BM) involvement, prognosis is usually poor (Avasthi et al., 2010, Qasim et al., 2003, and Singh et al., 2001). We, hereby, report a case of extra-pulmonary TB with a six-month history of fever associated with dizziness, fatigability, and cough. During the hospital stay, the patient showed a spectrum of interesting hematological findings, including severe pancytopenia on peripheral smear, necrotizing caseating granulomas consistent with TB on bone marrow examination. The patient showed a good clinical as well as hematological response to antituberculosis treatment. This paper highlights the significance of a hematological picture in the final confirmation of TB, which may otherwise be passed off as nutritional or other unrelated causes.

摘要

虽然肺外结核较为常见,但有时其临床表现多样,使诊断变得复杂(阿瓦斯蒂等人,2010年)。非特异性症状包括不明原因发热、肝脾肿大、淋巴结病、脑膜炎,以及罕见的各种血液学异常,即贫血、全血细胞减少和类白血病反应(阿瓦斯蒂等人,2010年)。当出现骨髓受累时,预后通常较差(阿瓦斯蒂等人,2010年;卡西姆等人,2003年;辛格等人,2001年)。在此,我们报告一例肺外结核病例,患者有6个月发热病史,伴有头晕、乏力和咳嗽。住院期间,患者出现了一系列有趣的血液学检查结果,包括外周血涂片显示严重全血细胞减少,骨髓检查发现与结核相符的坏死性干酪样肉芽肿。患者对抗结核治疗表现出良好的临床及血液学反应。本文强调了血液学表现对最终确诊结核的重要性,否则可能会被误诊为营养性或其他无关原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/3655508/b0ff6791a5db/CRIM.MEDICINE2013-353798.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/3655508/fffcceb043d3/CRIM.MEDICINE2013-353798.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/3655508/b0ff6791a5db/CRIM.MEDICINE2013-353798.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/3655508/fffcceb043d3/CRIM.MEDICINE2013-353798.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/3655508/b0ff6791a5db/CRIM.MEDICINE2013-353798.002.jpg

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本文引用的文献

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2
[Pancytopenia in disseminated tuberculosis: Think of macrophage activation syndrome].[播散性结核病中的全血细胞减少:考虑巨噬细胞活化综合征]
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[A clinical analysis of 20 cases with bone marrow granulomas].20例骨髓肉芽肿的临床分析
Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art.
活动性结核病治疗期间常见和罕见的血液学表现及药物不良事件:现状
Microorganisms. 2021 Jul 9;9(7):1477. doi: 10.3390/microorganisms9071477.
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Pancytopenia without Hepatosplenomegaly: A Rare Manifestation of Extrapulmonary Tuberculosis in an Adolescent Boy.无肝脾肿大的全血细胞减少:一名青少年男性肺外结核的罕见表现
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J Med Case Rep. 2018 Mar 6;12(1):58. doi: 10.1186/s13256-018-1596-0.
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A Rare Case of Disseminated Tuberculosis of the Bone Marrow in Systemic Lupus Erythematosus: Case Report.系统性红斑狼疮合并骨髓播散性结核1例:病例报告
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