Department of Chemistry and Combinatorial Chemistry Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
J Org Chem. 2010 Jan 1;75(1):253-6. doi: 10.1021/jo9022765.
The synthesis of unsymmetrical bisalkoxysilanes containing unsaturated C-C bonds and alkyl and aryl bromides has been developed. This method is a modification of our previously reported two-step procedure that utilizes readily available catalysts (rhodium acetate dimer and manganese pentacarbonyl bromide) under mild neutral aprotic conditions. Good to moderate yields of the products were obtained in a short period. In this two-step synthesis, unsymmetrical bisalkoxysilanes with groups that can be further functionalized can be prepared effectively without the need to isolate the intermediates.
开发了一种含有不饱和 C-C 键和烷基及芳基溴化物的不对称双烷氧基硅烷的合成方法。该方法是对我们之前报道的两步法的改进，该方法在温和的中性非质子条件下使用易得的催化剂（醋酸铑二聚体和五羰基溴化锰）。该两步合成法中，无需分离中间体，即可有效地制备可进一步官能化的具有特定基团的不对称双烷氧基硅烷，得到的产物产率良好至中等。
