通过Petasis反应一锅法合成新型稠合的4,5-桥连1,2,5-三氮杂卓-3,6-二酮、1,2,5-三氮杂卓-3,7-二酮杂环化合物。
One-pot synthesis of new fused 4,5-bridged 1,2,5-triazepine-3,6-diones, 1,2,5-triazepine-3,7-diones heterocycles by Petasis reaction.
作者信息
Neogi Subhasish, Roy Amrita, Naskar Dinabandhu
机构信息
Syngene International Ltd, Biocon Park, Plot No. 2 & 3, Bommasandra IV Phase, Bangalore, India.
出版信息
J Comb Chem. 2010 Jan-Feb;12(1):75-83. doi: 10.1021/cc900092x.
PMID:19954206
Abstract
The one pot synthesis of a new fused 1,2,5-triazepine-3,6-diones, 1,2,5-triazepine-3,7-diones heterocyles has been described via Petasis reactions. These heterocycles might be suitable for elaboration into larger peptides at amino termini. The scope and limitations of this method have been examined.
摘要
通过Petasis反应描述了一种新型稠合的1,2,5 - 三氮杂卓 - 3,6 - 二酮、1,2,5 - 三氮杂卓 - 3,7 - 二酮杂环的一锅法合成。这些杂环可能适合在氨基末端扩展成更大的肽。已经研究了该方法的适用范围和局限性。
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