银和金介导的多米诺转化：一种合成苯并[e]吲哚[1,2-a]吡咯并/吡啶[2,1-c][1,4]二氮杂环庚三酮-3,9-二酮的策略。

Silver- and gold-mediated domino transformation: a strategy for synthesizing benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c][1,4]diazepine-3,9-diones.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

出版信息

J Org Chem. 2011 Mar 4;76(5):1239-49. doi: 10.1021/jo101727r. Epub 2011 Feb 3.

DOI:10.1021/jo101727r

PMID:21291254

Abstract

We reported a strategy for the synthesis of fused heterocyclic compounds benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c][1,4]diazepine-3,9-diones via an AgSbF(6)/gold-complex catalyzed one-pot cascade transformation. The strategy is tolerant of a broad range of substrates and affords a series of intriguing fused diazepinedione heterocycles.

摘要

我们报道了一种通过 AgSbF(6)/金配合物催化一锅级联转化合成并环杂环化合物苯并[e]吲哚并[1,2-a]吡咯并[2,1-c][1,4]二氮杂环庚三酮-3,9-二酮的策略。该策略对广泛的底物具有耐受性，并提供了一系列有趣的并环二氮杂酮杂环。