Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan.
Drug Dev Ind Pharm. 2010 Jun;36(6):625-31. doi: 10.3109/03639040903406126.
A high-pressure wet-type jet mill is a powerful equipment used for the dispersion and emulsification of substances. In this study, we investigated its usefulness in the preparation of skin cream formulations.
We prepared a hydrophilic ointment base as a typical skin cream base, and then treated it with the wet-type jet mill under different conditions. Controllable factors of the wet-type jet mill included processing pressure, treatment cycle, and temperature of the treatment.
Treatment with the wet-type jet mill had a great impact on the rheological characteristics of the hydrophilic ointment base. The hysteresis areas and yield values of the treated ointments were significantly increased by increasing the processing pressure and temperature during the treatment. From scanning electron microscopic observations, the oil droplet size of the hydrophilic ointments decreased after treatment with the wet-type jet mill, suggesting that a decrease in oil droplet size mediates changes in the rheological characteristics.
Because we can expect the wet-type jet mill to control the rheological characteristics of the ointment, it is a promising tool for the preparation of skin cream formulations.
高压湿法粉碎机是一种强大的设备，用于物质的分散和乳化。本研究探讨了其在皮肤乳膏制剂制备中的应用。
我们制备了亲水性软膏基质作为典型的乳膏基质，然后在不同条件下用湿法粉碎机进行处理。湿法粉碎机的可控因素包括加工压力、处理周期和处理温度。
湿法粉碎机的处理对亲水性软膏基质的流变性有很大影响。通过增加处理过程中的加工压力和温度，处理后的软膏的滞后面积和屈服值显著增加。从扫描电子显微镜观察结果来看，亲水性软膏的油滴粒径在经过湿法粉碎机处理后减小，表明油滴粒径的减小介导了流变特性的变化。
由于我们可以期望湿法粉碎机控制软膏的流变性，因此它是制备皮肤乳膏制剂的有前途的工具。
