Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Clin Exp Allergy. 2009 Oct;39(10):1477-81. doi: 10.1111/j.1365-2222.2009.03354.x.
Allergic asthma is usually diagnosed by the presence of variable airway obstruction, bronchial hyperresponsiveness, and allergy. However, a significant proportion of adult asthma patients (up to 40%) are non-allergic. Patients with non-allergic asthma often have a later disease onset and greater disease severity, as reflected by more severe airway obstruction and bronchial hyperresponsiveness. Furthermore, females have a higher risk of developing non-allergic asthma. The latter suggests that hormone-related events play an important role in the development and severity of adult-onset non-allergic asthma. This paper describes the associations between asthma and hormonal changes throughout the female life-span, such as those associated with the monthly cycle of menstruation and menopausal hormonal changes.
变应性哮喘通常通过气道阻塞的可变性、支气管高反应性和过敏来诊断。然而，相当一部分成年哮喘患者（高达 40%）是非变应性的。非变应性哮喘患者的疾病发作通常较晚，疾病严重程度更高，表现为更严重的气道阻塞和支气管高反应性。此外，女性患非变应性哮喘的风险更高。这表明激素相关事件在成年起病的非变应性哮喘的发生和严重程度中发挥重要作用。本文描述了哮喘与女性整个生命周期中激素变化之间的关联，例如与月经周期和绝经后激素变化相关的关联。
