通过人恶性肿瘤细胞与原代小鼠胚胎细胞融合产生杂交细胞。
Production of hybrid cells by fusion of human malignant tumour cells and primary mouse embryo cells.
作者信息
Watkins J F
出版信息
Int J Cancer. 1977 Oct 15;20(4):535-42. doi: 10.1002/ijc.2910200410.
PMID:199545
Abstract
Hybrid cells with a subtetraploid mouse chromosome complement were produced by fusion of three types of human tumour cells with primary mouse embryo cells. The most frequently present presumptive human chromosome was 21. Numerous chromosome rearrangements were present. Some hybrid cells produced regressing tumours in mice.
摘要
通过将三种人类肿瘤细胞与原代小鼠胚胎细胞融合，产生了具有亚四倍体小鼠染色体组的杂交细胞。最常出现的推定人类染色体是21号染色体。存在大量染色体重排。一些杂交细胞在小鼠体内产生了逐渐消退的肿瘤。
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