牛型分枝杆菌卡介苗（BCG）东京株通过内化抑制 HeLa 细胞生长。
Growth inhibition of HeLa cell by internalization of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) Tokyo.
机构信息
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan.
出版信息
Cancer Cell Int. 2009 Dec 2;9:30. doi: 10.1186/1475-2867-9-30.
BACKGROUND
Intravesical BCG immunotherapy is effective for preventing recurrence and progression in none muscle-invasive bladder cancer but the dosing schedule and duration of treatment remain empirical. The mechanisms by which intravesical BCG treatment mediates antitumor activity are currently poorly understood.
RESULTS
HeLa cell infected with Mycobacterium bovis Bacillus Calmette-Guérin(BCG) Tokyo which were different multiplicity of infection(MOI). Proliferation of HeLa cell reduced in a dose-dependent manner by live BCG. The cytoplasm of the HeLa cell showed variety lysosomal stages by internalized and interacted BCG.
CONCLUSION
Proliferated Live BCG secreted the protein and depressed the growth of tumor. The possibility for clinical introduction of BCG therapy for carcinoma reported with review of literature.
背景
膀胱内卡介苗免疫疗法对预防非肌肉浸润性膀胱癌的复发和进展有效，但治疗的剂量方案和持续时间仍然是经验性的。目前，膀胱内卡介苗治疗介导抗肿瘤活性的机制还知之甚少。
结果
用牛分枝杆菌卡介苗（BCG）东京株感染的 HeLa 细胞，其感染复数（MOI）不同。活 BCG 以剂量依赖性方式降低 HeLa 细胞的增殖。HeLa 细胞的细胞质通过内化和相互作用的 BCG 显示出各种溶酶体阶段。
结论
增殖的活 BCG 分泌蛋白质并抑制肿瘤的生长。通过文献复习报告了卡介苗治疗癌的临床应用的可能性。
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