Instituto de Desarrollo e Investigaciones Pediátricas Prof. Fernando E. Viteri (IDIP), Hospital de Niños de La Plata (MS/CIC-PBA), 63 N 1069 La Plata CP 1900, Argentina.
Public Health Nutr. 2010 Oct;13(10):1522-7. doi: 10.1017/S1368980009992199. Epub 2009 Dec 3.
Bone mineral density (BMD) loss has been described in adult women in the 12-month postpartum period. However, little is known about the precise BMD pattern in adolescent mothers. The present study aimed to evaluate BMD in Argentinean adolescent mothers followed up during the 12-month postpartum period.
Analytical, prospective clinical trial. BMD and body composition were determined by dual-energy X-ray absorptiometry; bone mineral content (BMC) and BMD were measured in the lumbar spine (L2-L4), femoral neck (FN), femur trochanter (TR), total hip (TH) and total body. Changes in BMD and BMC were analysed using ANOVA for pairwise comparisons. Other comparisons were performed with the paired-sample t test and Wilcoxon test; Pearson's correlation coefficient was used to analyse the relationship among continuous variables.
La Plata, Argentina.
Adolescent mothers (n 35; 17 years old or less) were recruited within 15 d after delivery. Studies and follow-up were performed at 15 d and 3, 6 and 12 months postpartum.
BMD and BMC losses at 3 and 6 months and recovery at 12 months fitted a quadratic curve (ANOVA) at the three sites studied (FN, TH, TR), in total-body BMD (P = 0.000) and BMC (P = 0.038). At hip sites, BMD loss occurred at 3 months (FN, P = 0.000; TR, P = 0.000; TH, P = 0.000) and 6 months (FN, P = 0.000; TR, P = 0.000; TH, P = 0.000) compared with basal values. Percentage BMD loss immediately after delivery up to 6 months was about 5 %.
Adolescents showed significant BMD and BMC losses at 6 months postpartum, with an almost total recovery at 12 months in all sites studied.
已有研究描述了产后 12 个月的成年女性会出现骨密度（BMD）丢失的现象。但是，关于青少年母亲骨密度的确切变化模式，目前还知之甚少。本研究旨在评估阿根廷青少年母亲在产后 12 个月内的 BMD 变化情况。
分析性、前瞻性临床试验。采用双能 X 射线吸收法测定 BMD 和身体成分；测量腰椎（L2-L4）、股骨颈（FN）、股骨大转子（TR）、全髋（TH）和全身的骨矿物质含量（BMC）和 BMD。采用方差分析（ANOVA）进行两两比较，分析 BMD 和 BMC 的变化情况。其他比较采用配对样本 t 检验和 Wilcoxon 检验；采用 Pearson 相关系数分析连续变量之间的关系。
阿根廷拉普拉塔。
招募了 35 名青少年母亲（年龄在 17 岁及以下），她们在产后 15 天内参加了研究。研究和随访分别在产后 15 天和 3、6、12 个月进行。
3 个月和 6 个月时 BMD 和 BMC 丢失，12 个月时恢复，这与三种研究部位（FN、TH、TR）的二次曲线（ANOVA）相吻合，包括全身 BMD（P=0.000）和 BMC（P=0.038）。在髋部，3 个月时（FN，P=0.000；TR，P=0.000；TH，P=0.000）和 6 个月时（FN，P=0.000；TR，P=0.000；TH，P=0.000）与基础值相比，BMD 丢失。产后即刻至 6 个月的 BMD 丢失率约为 5%。
青少年在产后 6 个月时出现明显的 BMD 和 BMC 丢失，但所有研究部位在 12 个月时几乎完全恢复。
