Guidroz Julie A, Johnson Matthew T, Scott-Conner Carol E H, De Young Barry R, Weigel Ronald J
Department of Surgery, University of Iowa, Iowa City, IA, USA.
Am J Surg. 2010 Jun;199(6):792-6. doi: 10.1016/j.amjsurg.2009.06.020. Epub 2009 Dec 2.
This study was undertaken to evaluate the accuracy of touch preparation (touch prep) in the evaluation of sentinel lymph nodes (SLNs).
We performed a retrospective review of 402 breast cancer patients who underwent SLN biopsy.
A SLN was identified in 381 patients. Of 61 patients with a true positive result, 59 underwent axillary node dissection, and in 22 the SLN was the only node with metastases. Thirty-six (9.44%) had at least 1 false negative result. Twenty-five with a false negative results were due to macrometastases, with 17 (2.4%) false negatives occurring in patients with invasive ductal and 6 (5.5%) in those with invasive lobular histology, P = .04. Touch prep had an overall sensitivity of 62.89% and specificity of 98.94%.
Touch prep for the evaluation of SLNs in breast cancer compares favorably to reported results for frozen section. False negative findings are more likely with micrometastases and invasive lobular histology.
本研究旨在评估触摸准备（触摸涂片）在前哨淋巴结（SLN）评估中的准确性。
我们对402例行SLN活检的乳腺癌患者进行了回顾性研究。
381例患者发现了SLN。在61例真阳性结果的患者中，59例行腋窝淋巴结清扫术，其中22例SLN是唯一有转移的淋巴结。36例（9.44%）至少有1例假阴性结果。25例假阴性结果是由于大转移灶所致，其中17例（2.4%）假阴性发生在浸润性导管癌患者中，6例（5.5%）发生在浸润性小叶癌组织学类型的患者中，P = 0.04。触摸涂片的总体敏感性为62.89%，特异性为98.94%。
乳腺癌SLN评估中触摸涂片与冷冻切片的报告结果相比具有优势。微转移灶和浸润性小叶癌组织学类型更易出现假阴性结果。
