还原激活的丝裂霉素 C 与碳酸氢盐水溶液的反应：顺式-1-羟基-2,7-二氨基-丝裂霉素烯的恶唑烷酮衍生物的分离与表征。

Reaction of reductively activated mitomycin C with aqueous bicarbonate: Isolation and characterization of an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosene.

机构信息

Departamento de Química Orgánica, Facultade de Ciencias, Universidade de Santiago de Compostela, Campus de Lugo, 27002 Lugo, Spain.

出版信息

Bioorg Med Chem Lett. 2010 Jan 1;20(1):31-4. doi: 10.1016/j.bmcl.2009.11.046. Epub 2009 Nov 15.

DOI:10.1016/j.bmcl.2009.11.046

PMID:19954979

Abstract

The reductive activation of mitomycin C in aqueous bicarbonate buffer resulted in the formation of a previously unknown compound, characterized as an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosene. This compound is the result of a cyclization reaction of bicarbonate with the aziridine ring of aziridinomitosene, and was observed at bicarbonate concentrations close to those present in physiological plasma.

摘要

在碳酸氢盐缓冲液中，丝裂霉素 C 的还原活化导致了一种以前未知的化合物的形成，该化合物被鉴定为顺-1-羟基-2,7-二氨基丝裂霉素烯的恶唑烷酮衍生物。这种化合物是碳酸根与氮丙啶基丝裂霉素烯的氮丙啶环发生环化反应的结果，并且在接近生理血浆中存在的浓度的碳酸根浓度下观察到。