Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmàcia, and Institute of Biomedicine, Universitat de Barcelona, Av Diagonal, 643, Barcelona E-08028, Spain.
Bioorg Med Chem. 2010 Jan 1;18(1):46-57. doi: 10.1016/j.bmc.2009.11.017. Epub 2009 Nov 14.
The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.
报告了几种（1,2,3,5,6,7-六氢-1,5:3,7-二甲撑-4-苯并恶嗪-3-基）胺及其相关化合物的合成。其中一些化合物显示出与美金刚类似的作为 NMDA 受体拮抗剂的活性。一些衍生物表现出显著的抗锥虫活性。
