具有 NMDA 受体拮抗剂和杀锥虫活性的新型稠合多环笼状胺。
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
机构信息
Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmàcia, and Institute of Biomedicine, Universitat de Barcelona, Av Diagonal, 643, Barcelona E-08028, Spain.
出版信息
Bioorg Med Chem. 2010 Jan 1;18(1):46-57. doi: 10.1016/j.bmc.2009.11.017. Epub 2009 Nov 14.
PMID:19954985
Abstract
The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.
摘要
报告了几种（1,2,3,5,6,7-六氢-1,5:3,7-二甲撑-4-苯并恶嗪-3-基）胺及其相关化合物的合成。其中一些化合物显示出与美金刚类似的作为 NMDA 受体拮抗剂的活性。一些衍生物表现出显著的抗锥虫活性。
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