Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India.
J Trop Pediatr. 2010 Aug;56(4):278-9. doi: 10.1093/tropej/fmp118. Epub 2009 Dec 2.
The emergence of ciprofloxacin resistance in Shigella has shifted the attention to cephalosporins. The first occurrence of third generation cephalosporin-resistant Shigella flexneri was from France. This article reports the first case of cephalosporin-resistant S. flexneri from India. A 12-month-old child was admitted for a 20-day episode of loose stools, non-fetid, with mucus and blood. The stool sample showed the presence of blood and mucus and S. flexneri which was resistant to Ampicillin, Nalidixic acid, Ciprofloxacin, Furoxone, Ceftriaxone and sensitive only to Cefoperazone and sulbactam combination. The child was promptly admitted and treated with a combination of Cefoperazone and sulbactam. The use of this combination was met with success in the present case, and may be considered as a temporary answer to the emerging cephalosporin-resistance.
志贺菌中出现的环丙沙星耐药性已将人们的注意力转移到头孢菌素上。首例第三代头孢菌素耐药福氏志贺菌是在法国发现的。本文报告了印度首例头孢菌素耐药福氏志贺菌。一名 12 个月大的儿童因腹泻 20 天而入院，大便稀，有臭味，有黏液和血。粪便样本显示有血液和黏液，以及对氨苄西林、萘啶酸、环丙沙星、呋喃妥因、头孢曲松耐药，仅对头孢哌酮和舒巴坦组合敏感。该儿童立即入院，并接受头孢哌酮和舒巴坦联合治疗。在本病例中，该组合的使用取得了成功，可作为对抗新兴头孢菌素耐药性的临时对策。
