Unit of Reproductive Endocrinology Unit for Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Papageorgiou General Hospital, Aristotle University, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece.
Eur J Endocrinol. 2010 Apr;162(4):643-52. doi: 10.1530/EJE-09-0850. Epub 2009 Dec 2.
To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF.
Meta-analysis of observational studies.
PATIENT(S): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis.
Miscarriage risk ratio (RR).
Clinical pregnancy rate and delivery rate.
RESULT(S): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups.
Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
探讨甲状腺自身免疫（TAI）是否与接受体外受精（IVF）的亚生育力、甲状腺功能正常女性自然流产风险增加有关。
观察性研究的荟萃分析。
纳入了四项前瞻性研究，这些研究报告了 1098 名接受 IVF 的亚生育力女性（141 名患有 TAI，957 名对照组）的数据。
流产风险比（RR）。
临床妊娠率和分娩率。
甲状腺功能正常、患有 TAI 的接受 IVF 的亚生育力女性与对照组相比，流产风险显著增加（四项研究固定效应 RR：1.99，95%置信区间：1.42-2.79，P<0.001）。两组间临床妊娠率和分娩率无显著差异。
根据目前的证据，甲状腺自身免疫的存在似乎与通过 IVF 程序受孕的亚生育力女性自然流产风险增加有关。
