Department of Hematology/Oncology, University of Oklahoma, Oklahoma City, OK, USA.
Am J Ther. 2009 Sep-Oct;16(5):412-20. doi: 10.1097/MJT.0b013e3181907ed9.
The treatment of metastatic colorectal cancer has undergone major advances yielding significant improvements in survival over the past decade. These advances have evolved due to the benefits of combination chemotherapy and the incorporation of biologic therapy. However, as we struggle to provide optimum care while sparing patients ineffective therapy and undue cost, the importance of tailored therapy to maximize benefit will become increasingly important. This article reviews the major advances in the treatment of patients with metastatic colorectal cancer and the burgeoning developments in individualized therapy.
过去十年中，转移性结直肠癌的治疗取得了重大进展，显著提高了患者的生存率。这些进展源于联合化疗的益处和生物治疗的应用。然而，随着我们努力在为患者提供最佳治疗的同时避免无效治疗和不必要的成本，针对患者进行个体化治疗以实现最大获益的重要性将日益凸显。本文回顾了转移性结直肠癌治疗方面的主要进展以及个体化治疗方面的新兴发展。
