Department of Viruses, Hormones, and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.
Sex Transm Dis. 2009 Oct;36(10):609-15. doi: 10.1097/OLQ.0b013e3181a96d0e.
Human papillomavirus (HPV) is the cause of cervical cancer. To better understand the natural history of HPV, we assessed the incidence of type-specific HPV infection and examined risk factors for acquisition of high-risk (HR) HPV infection in Danish women.
A population-based prospective cohort study of women aged 20 to 29 years was conducted. Participants were interviewed and underwent 2 gynaecological examinations 2 years apart. Women for whom Hybrid Capture 2 results were available at both visits were included in the analysis (n = 7454).
A HR HPV infection was acquired by 12.8% of the women during follow-up. The incidence decreased with increasing age. The commonest types were HPV16, HPV31, and HPV52. HPV66, HPV58, and HPV53 were mainly acquired with other HR types. Multiple HR types were acquired in 50% of the women who became HPV-positive during follow-up. In initially HPV-negative women age, number of sexual partners, and oral contraceptive use were the main risk factors for acquisition, particularly of multiple HR HPV types.
HPV infections were commonly acquired. We confirmed the sexually transmitted nature of the infection. Our findings show that both the level of potential exposure and other behavioral factors increase the risk for HR HPV acquisition.
人乳头瘤病毒（HPV）是宫颈癌的病因。为了更好地了解 HPV 的自然史，我们评估了丹麦女性特定类型 HPV 感染的发生率，并研究了获得高危（HR）HPV 感染的危险因素。
对 20-29 岁的女性进行了一项基于人群的前瞻性队列研究。参与者接受了访谈，并在 2 年内进行了 2 次妇科检查。在两次就诊时均有 Hybrid Capture 2 结果的女性被纳入分析（n=7454）。
在随访期间，12.8%的女性感染了高危 HPV。发病率随年龄增长而降低。最常见的类型是 HPV16、HPV31 和 HPV52。HPV66、HPV58 和 HPV53 主要与其他 HR 型一起获得。在随访期间 HPV 转为阳性的女性中，有 50%的人同时感染了多种 HR 型 HPV。在最初 HPV 阴性的女性中，年龄、性伴侣数量和口服避孕药的使用是感染的主要危险因素，尤其是多种 HR HPV 类型的感染。
HPV 感染很常见。我们证实了这种感染的性传播性质。我们的研究结果表明，潜在暴露水平和其他行为因素都会增加感染高危 HPV 的风险。
