Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China.
J Clin Rheumatol. 2009 Dec;15(8):389-92. doi: 10.1097/RHU.0b013e3181c3f87e.
Drug-induced acute pneumonitis is a rare but potentially fatal adverse drug reaction. A high index of suspicion is needed for early diagnosis as it mimics community acquired pneumonia and interstitial lung disease that can occur in rheumatoid arthritis. We report a 32-year-old Chinese lady who suffered from leflunomide-induced pneumonitis and improved dramatically after receiving cholestyramine wash-out therapy. This case illustrates the need for clinical alertness to this potentially fatal complication. When in doubt, discontinuation of leflunomide and empirical wash-out therapy should be administered without delay.
药物性急性肺炎是一种罕见但可能致命的药物不良反应。由于其类似于类风湿关节炎中可能发生的社区获得性肺炎和间质性肺病，因此需要高度怀疑以进行早期诊断。我们报告了一例 32 岁的中国女性，她患有来氟米特诱导性肺炎，在接受考来烯胺冲洗治疗后病情显著改善。该病例说明了对这种潜在致命并发症保持临床警惕的必要性。如有疑问，应毫不犹豫地停用来氟米特并进行经验性冲洗治疗。
