整合素在前列腺癌进展中的作用
Integrins in prostate cancer progression.
作者信息
Goel Hira Lal, Li Jing, Kogan Sophia, Languino Lucia R
机构信息
Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
出版信息
Endocr Relat Cancer. 2008 Sep;15(3):657-64. doi: 10.1677/ERC-08-0019. Epub 2008 Jun 4.
Abstract
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.
摘要
整合素是细胞外基质蛋白的跨膜受体，在细胞存活、增殖、迁移、基因表达以及生长因子受体激活中发挥关键作用。它们的功能和表达在包括前列腺癌在内的多种癌症类型中失调。在本文中，我们综述了整合素在前列腺癌进展中的作用及其作为治疗靶点的潜力。
相似文献
1
Integrins in prostate cancer progression.整合素在前列腺癌进展中的作用
Endocr Relat Cancer. 2008 Sep;15(3):657-64. doi: 10.1677/ERC-08-0019. Epub 2008 Jun 4.
2
miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer.miR-195通过靶向人前列腺癌中的RPS6KB1抑制肿瘤进展。
Clin Cancer Res. 2015 Nov 1;21(21):4922-34. doi: 10.1158/1078-0432.CCR-15-0217. Epub 2015 Jun 16.
3
Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.外泌体 αvβ6 整联蛋白是前列腺癌中单核细胞 M2 极化所必需的。
Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9.
4
Therapeutic Value of an Integrin Antagonist in Prostate Cancer.整合素拮抗剂在前列腺癌中的治疗价值
Curr Drug Targets. 2016;17(3):321-7. doi: 10.2174/1389450117666151209115324.
5
Integrins: roles in cancer development and as treatment targets.整合素：在癌症发展中的作用及作为治疗靶点
Br J Cancer. 2004 Feb 9;90(3):561-5. doi: 10.1038/sj.bjc.6601576.
6
SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.SKI-606（博舒替尼）通过调节与癌症生长和骨骼转移相关的基因，在体外和体内阻断前列腺癌的侵袭、生长和转移。
Mol Cancer Ther. 2010 May;9(5):1147-57. doi: 10.1158/1535-7163.MCT-09-0962. Epub 2010 Apr 27.
7
Integrins in bone metastasis formation and potential therapeutic implications.整合素在骨转移形成中的作用及其潜在的治疗意义。
Curr Cancer Drug Targets. 2009 Nov;9(7):801-6. doi: 10.2174/156800909789760348.
8
CD147/EMMPRIN and CD44 are potential therapeutic targets for metastatic prostate cancer.CD147/EMMPRIN 和 CD44 是转移性前列腺癌潜在的治疗靶点。
Curr Cancer Drug Targets. 2010 May;10(3):287-306. doi: 10.2174/156800910791190193.
9
Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).前列腺癌细胞中Id-1的过表达通过激活血管内皮生长因子（VEGF）促进血管生成。
Carcinogenesis. 2005 Oct;26(10):1668-76. doi: 10.1093/carcin/bgi128. Epub 2005 May 19.
10
Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation.雄激素受体通过差异改变 miRNA525-5p/SLPI 介导的血管生成拟态形成来抑制前列腺癌转移但促进膀胱癌转移。
Cancer Lett. 2020 Mar 31;473:118-129. doi: 10.1016/j.canlet.2019.12.018. Epub 2019 Dec 13.
引用本文的文献
1
Interplay of integrins and selectins in metastasis.整合素与选择素在转移中的相互作用。
Mol Oncol. 2025 Jun;19(6):1582-1611. doi: 10.1002/1878-0261.70026. Epub 2025 May 6.
2
Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer.作为前列腺癌转移级联驱动因素的内体-溶酶体囊泡机制的组成部分
Cancers (Basel). 2024 Dec 26;17(1):43. doi: 10.3390/cancers17010043.
3
Apoptosis-Cell Cycle-Autophagy Molecular Mechanisms Network in Heterogeneous Aggressive Phenotype Prostate Hyperplasia Primary Cell Cultures Have a Prognostic Role.异质性侵袭表型前列腺增生原代细胞培养物中细胞凋亡-细胞周期-自噬分子机制网络具有预后作用。
Int J Mol Sci. 2024 Aug 28;25(17):9329. doi: 10.3390/ijms25179329.
4
A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery.一种基于海洋胶原蛋白的 3D 支架，用于体外构建人类前列腺癌微环境模型和抗癌治疗药物的发现。
Mar Drugs. 2024 Jun 26;22(7):295. doi: 10.3390/md22070295.
5
Microfluidic-based human prostate-cancer-on-chip.基于微流控技术的人体前列腺癌芯片
Front Bioeng Biotechnol. 2024 Jan 23;12:1302223. doi: 10.3389/fbioe.2024.1302223. eCollection 2024.
6
Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer.整合素αvβ3/α6β1 在前列腺癌预后和免疫逃逸中的综合分析。
Aging (Albany NY). 2023 Oct 19;15(20):11369-11388. doi: 10.18632/aging.205131.
7
Irisin Induces Apoptosis in Metastatic Prostate Cancer Cells and Inhibits Tumor Growth In Vivo.鸢尾素诱导转移性前列腺癌细胞凋亡并在体内抑制肿瘤生长。
Cancers (Basel). 2023 Aug 7;15(15):4000. doi: 10.3390/cancers15154000.
8
Targeting integrin α5β1 in urological tumors: opportunities and challenges.靶向整合素α5β1在泌尿系统肿瘤中的应用：机遇与挑战
Front Oncol. 2023 Jul 6;13:1165073. doi: 10.3389/fonc.2023.1165073. eCollection 2023.
9
Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression.靶向 ATF6 介导的内质网应激反应和自噬可阻断整合素驱动的前列腺癌进展。
Mol Cancer Res. 2023 Sep 1;21(9):958-974. doi: 10.1158/1541-7786.MCR-23-0108.
10
Anoikis in phenotypic reprogramming of the prostate tumor microenvironment.细胞失巢凋亡在前列腺肿瘤微环境表型重编程中的作用。
Front Endocrinol (Lausanne). 2023 Apr 5;14:1160267. doi: 10.3389/fendo.2023.1160267. eCollection 2023.
本文引用的文献
1
Cancer statistics, 2008.2008年癌症统计数据。
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96. doi: 10.3322/CA.2007.0010. Epub 2008 Feb 20.
2
18F-labeled BBN-RGD heterodimer for prostate cancer imaging.用于前列腺癌成像的18F标记的BBN-RGD异二聚体
J Nucl Med. 2008 Mar;49(3):453-61. doi: 10.2967/jnumed.107.048009. Epub 2008 Feb 20.
3
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.整合素αvβ6的抗体介导性阻断通过转化生长因子-β调节机制在体内抑制肿瘤进展。
Cancer Res. 2008 Jan 15;68(2):561-70. doi: 10.1158/0008-5472.CAN-07-2307.
4
CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells.CNTO 95，一种完全人源化的抗αv整合素抗体，可抑制人乳腺癌细胞的细胞信号传导、迁移、侵袭和自发转移。
Clin Exp Metastasis. 2008;25(2):139-48. doi: 10.1007/s10585-007-9132-4. Epub 2007 Dec 5.
5
alpha6 integrin cleavage: sensitizing human prostate cancer to ionizing radiation.α6整合素裂解：使人类前列腺癌对电离辐射敏感
Int J Radiat Biol. 2007 Nov-Dec;83(11-12):761-7. doi: 10.1080/09553000701633135.
6
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers.癌症干细胞/祖细胞研究的最新进展：克服对最具侵袭性癌症耐药性的治疗意义
J Cell Mol Med. 2007 Sep-Oct;11(5):981-1011. doi: 10.1111/j.1582-4934.2007.00088.x.
7
Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line.α-6整合素对于MCF7乳腺癌细胞系中一个干细胞样亚群的致瘤性是必需的。
Int J Cancer. 2008 Jan 15;122(2):298-304. doi: 10.1002/ijc.23103.
8
Integrins and cancer.整合素与癌症
Oncology (Williston Park). 2007 Aug;21(9 Suppl 3):13-20.
9
The integrin-growth factor receptor duet.整合素-生长因子受体二重奏
J Cell Physiol. 2007 Dec;213(3):649-53. doi: 10.1002/jcp.21278.
10
Targeting vasculature in urologic tumors: mechanistic and therapeutic significance.靶向泌尿系统肿瘤中的脉管系统：机制与治疗意义
J Cell Biochem. 2008 Feb 15;103(3):691-708. doi: 10.1002/jcb.21442.
Zotero 插件