14-3-3西格玛，人类癌症的双刃剑。
14-3-3sigma, the double-edged sword of human cancers.
作者信息
Li Zhaomin, Liu Jing-Yuan, Zhang Jian-Ting
机构信息
Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University School of Medicine Indianapolis, IN 46202, USA.
出版信息
Am J Transl Res. 2009 Jun 8;1(4):326-40.
Abstract
14-3-3sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3sigma has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3sigma may also predict poor prognosis in some human cancers. Thus, 14-3-3sigma may play an important role as a double-edged sword in human cancers, which may attribute to its property as a molecular chaperone by binding to various protein ligands important to many cellular processes such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will review recent studies and progresses in understanding 14-3-3sigma as a double-edged sword in human cancers.
摘要
14-3-3σ是14-3-3蛋白高度保守家族的成员之一，存在于所有真核生物中。14-3-3σ被认为是一种肿瘤抑制因子，在某些人类癌症中表达降低，而其表达增加会导致对引起DNA损伤的抗癌药物和辐射产生抗性。14-3-3σ表达增加也可能预示某些人类癌症的预后不良。因此，14-3-3σ在人类癌症中可能扮演着双刃剑的重要角色，这可能归因于其作为分子伴侣的特性，通过与许多细胞过程（如细胞周期检查点调节和对DNA损伤的凋亡反应）中重要的各种蛋白质配体结合。在本文中，我们将综述关于14-3-3σ在人类癌症中作为双刃剑的最新研究和进展。
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