Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.
Int J Oncol. 2010 Jan;36(1):85-92.
RELN (Reelin) is an extracellular glycoprotein that plays a critical role in neuronal migration. Here we show that the RELN gene is frequently silenced in gastric cancers (GCs) by aberrant promoter hypermethylation. Although RELN was strongly expressed in non-tumor gastric epithelia, its expression was weak, or absent, in GC cell lines and primary GC tumors. Absence of RELN expression significantly correlated with a more advanced stage of GC. Methylation of the RELN promoter was frequently found in GC cell lines and in primary GC tumors. These findings suggest that disruption of the RELN pathway may be involved in gastric carcinogenesis.
RELN（Reelin）是一种细胞外糖蛋白，在神经元迁移中发挥关键作用。在这里，我们表明 RELN 基因通过异常启动子超甲基化在胃癌（GCs）中经常被沉默。尽管 RELN 在非肿瘤胃上皮中强烈表达，但在 GC 细胞系和原发性 GC 肿瘤中其表达较弱或缺失。RELN 表达的缺失与 GC 的更晚期显著相关。RELN 启动子的甲基化在 GC 细胞系和原发性 GC 肿瘤中经常被发现。这些发现表明，RELN 通路的破坏可能参与了胃癌的发生。
