Tomoda T, Ogura H, Kurashige T
Department of Pediatrics, Kochi Medical School, Japan.
J Infect Dis. 1991 Mar;163(3):559-63. doi: 10.1093/infdis/163.3.559.
To assess antibody and cellular immune responses, 156 healthy children were immunized at approximately 18 months of age with acellular diphtheria-tetanus-pertussis vaccine. Changes in antibody responses to filamentous hemagglutinin (FHA) and to pertussis toxin (PT) were similar in pattern, and antibody titers reached values equal to those from patients with convalescent-stage pertussis. The FHA-induced DNA synthesis in peripheral blood mononuclear cells was maximum at 4 weeks after the primary series, and these levels were equal to those of patients with pertussis. High amounts of PT-induced DNA synthesis were observed in both immunized and nonimmunized children; thus, PT seemed to act mainly as a nonspecific mitogen. Almost the same responses to several mitogens that activate different subsets of lymphocytes were observed in young infants compared with older children. Furthermore, young infants who had Bordetella pertussis infection responded by FHA stimulation almost as well as older children.
为评估抗体和细胞免疫反应，156名健康儿童在约18个月大时接种了无细胞白喉-破伤风-百日咳疫苗。对丝状血凝素（FHA）和百日咳毒素（PT）的抗体反应变化模式相似，抗体滴度达到与百日咳恢复期患者相当的值。FHA诱导外周血单核细胞中的DNA合成在初次接种系列后的4周时达到最大值，且这些水平与百日咳患者的水平相当。在免疫和未免疫的儿童中均观察到大量PT诱导的DNA合成；因此，PT似乎主要作为一种非特异性有丝分裂原起作用。与大龄儿童相比，在幼儿中观察到对几种激活不同淋巴细胞亚群的有丝分裂原的反应几乎相同。此外，感染百日咳博德特氏菌的幼儿对FHA刺激的反应几乎与大龄儿童一样好。
