School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Rapid Commun Mass Spectrom. 2010 Jan;24(1):15-20. doi: 10.1002/rcm.4351.
In recent years, Au-cluster ions have been successfully used for organic analysis in secondary ion mass spectrometry. Cluster ions, such as Au(2)(+) and Au(3)(+), can produce secondary ion yield enhancements of up to a factor of 300 for high mass organic molecules with minimal sample damage. In this study, the potential for using Au(+), Au(2)(+) and Au(3)(+) primary ions for the analysis of inorganic samples is investigated by analyzing a range of silicate glass standards. Practical secondary ion yields for both Au(2)(+) and Au(3)(+) ions are enhanced relative to those for Au(+), consistent with their increased sputter rates. No elevation in ionization efficiency was found for the cluster primary ions. Relative sensitivity factors for major and trace elements in the standards showed no improvement in quantification with Au(2)(+) and Au(3)(+) ions over the use of Au(+) ions. Higher achievable primary ion currents for Au(+) ions than for Au(2)(+) and Au(3)(+) allow for more precise analyses of elemental abundances within inorganic samples, making them the preferred choice, in contrast to the choice of Au(2)(+) and Au(3)(+) for the analysis of organic samples. The use of delayed secondary ion extraction can also boost secondary ion signals, although there is a loss of overall sensitivity.
近年来，金原子簇离子已成功用于二次离子质谱中的有机分析。金原子簇离子（如 Au(2)(+) 和 Au(3)(+)）可以将高分子量有机分子的二次离子产率提高高达 300 倍，同时对样品的损伤最小。在这项研究中，通过分析一系列硅酸盐玻璃标准品，研究了使用 Au(+)、Au(2)(+) 和 Au(3)(+) 初级离子分析无机样品的潜力。Au(2)(+) 和 Au(3)(+) 离子的实际二次离子产率相对于 Au(+)离子有所提高，这与它们较高的溅射率一致。对于簇状初级离子，没有发现电离效率的提高。标准中主要和微量元素的相对灵敏度因子表明，与使用 Au(+)离子相比，使用 Au(2)(+) 和 Au(3)(+) 离子对定量分析没有改善。与 Au(2)(+) 和 Au(3)(+) 相比，Au(+)离子具有更高的可实现初级离子电流，这使得它们能够更精确地分析无机样品中的元素丰度，因此成为首选，而不是选择 Au(2)(+) 和 Au(3)(+) 来分析有机样品。延迟二次离子提取也可以提高二次离子信号，尽管整体灵敏度会有所下降。
